CBL

Gene Symbol	CBL
Entrez Gene	867
Alt Symbol	C-CBL, CBL2, FRA11B, NSLL, RNF55
Species	Human
Gene Type	protein-coding
Description	Cbl proto-oncogene, E3 ubiquitin protein ligase
Other Description	Cas-Br-M (murine) ecotropic retroviral transforming sequence|E3 ubiquitin-protein ligase CBL|RING finger protein 55|casitas B-lineage lymphoma proto-oncogene|fragile site, folic acid type, rare, fra(11)(q23.3)|oncogene CBL2|proto-oncogene c-Cbl|signal transduction protein CBL
Swissprots	P22681 A3KMP8
Accessions	CAA57977 EAW67476 P22681 AA806454 AK092300 AL832396 BC132733 AAI32734 BC136463 AAI36464 BG722940 BX648139 DB457271 X57110 CAA40393 X69207 XM_011543057 XP_011541359 NM_005188 NP_005179
Function	Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be
Subcellular Location	Cytoplasm. Cell membrane. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Top Pathways	Proteoglycans in cancer, Ubiquitin mediated proteolysis, Bacterial invasion of epithelial cells, Endocytosis, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CBL Gene ORF cDNA clone in cloning vector - HG11594-M from Sino Biological Species Human

Human CBL Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11594-NF from Sino Biological Species Human

Human CBL Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11594-ACR from Sino Biological Species Human

Human CBL Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11594-CF from Sino Biological Species Human

Human CBL Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11594-NM from Sino Biological Species Human

Human CBL Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11594-CM from Sino Biological Species Human

Human CBL Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11594-ACG from Sino Biological Species Human

Human CBL Gene ORF cDNA clone expression plasmid - HG11594-UT from Sino Biological Species Human

Human CBL Gene ORF cDNA clone expression plasmid, N-HA tag - HG11594-NY from Sino Biological Species Human

Human CBL Gene ORF cDNA clone expression plasmid, N-His tag - HG11594-NH from Sino Biological Species Human

Human CBL Gene ORF cDNA clone expression plasmid, C-HA tag - HG11594-CY from Sino Biological Species Human

Human CBL Gene ORF cDNA clone expression plasmid, C-His tag - HG11594-CH from Sino Biological Species Human

Human CBL ORF clone (NM_005188.2) - CDCB160340 from Creative biogene Species Human

Human CBL gene - orb92717 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human CBL Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11594-ANG from Sino Biological Species Human

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