CBL

Gene Symbol	CBL
Entrez Gene	867
Alt Symbol	C-CBL, CBL2, FRA11B, NSLL, RNF55
Species	Human
Gene Type	protein-coding
Description	Cbl proto-oncogene, E3 ubiquitin protein ligase
Other Description	Cas-Br-M (murine) ecotropic retroviral transforming sequence|E3 ubiquitin-protein ligase CBL|RING finger protein 55|casitas B-lineage lymphoma proto-oncogene|fragile site, folic acid type, rare, fra(11)(q23.3)|oncogene CBL2|proto-oncogene c-Cbl|signal transduction protein CBL
Swissprots	P22681 A3KMP8
Accessions	CAA57977 EAW67476 P22681 AA806454 AK092300 AL832396 BC132733 AAI32734 BC136463 AAI36464 BG722940 BX648139 DB457271 X57110 CAA40393 X69207 XM_011543057 XP_011541359 NM_005188 NP_005179
Function	Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be
Subcellular Location	Cytoplasm. Cell membrane. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Top Pathways	Proteoglycans in cancer, Ubiquitin mediated proteolysis, Bacterial invasion of epithelial cells, Endocytosis, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CBL full length protein - ab114527 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human CBL peptide - ab22874 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human CBL protein fragment - ab114528 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Recombinant Human CBL Protein - H00000867-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CBL Protein - H00000867-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CBL Peptide - NBP1-76736PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

CBL-Antibody-C-term-Blocking-Peptide - BP4781b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CBL blocking peptide - GTX89954-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

CBL peptide - orb217027 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Cat

c-CBL (phospho-Tyr674) Blocking Peptide - abx062358 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken

c-CBL (phospho-Tyr774) Blocking Peptide - abx062359 from Abbexa Category Peptide Species Human, Mouse, Rat

CBL Peptide - AC21-0116-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CBL / RNF55 - H00000867-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CBL / RNF55 - H00000867-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CBL / RNF55 - H00000867-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CBL / RNF55 - H00000867-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CBL / RNF55 Control Peptide - AP30209CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

CBL Peptide - 45-028P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Mouse

Cbl Peptide - 3967P from ProSci Category Peptide Species Human

CBL fusion protein - Ag23033 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant E. coli metC Enzyme - BP002640-CG14 from Syd Labs Category Protein Prices $180.00, $528.00, $2,880.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Escherichia coli

Recombinant Human CBL - CBL-26492TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CBL - CBL-26493TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Ring Finger Protein 55 (RNF55) - RPE942Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

c-Cbl Protein, active - 23-041-K from EMD Millipore Category Protein Species Human

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