GJA1

Gene Symbol GJA1
Entrez Gene 2697
Alt Symbol AVSD3, CMDR, CX43, GJAL, HLHS1, HSS, ODDD
Species Human
Gene Type protein-coding
Description gap junction protein, alpha 1, 43kDa
Other Description connexin 43|connexin-43|gap junction 43 kDa heart protein|gap junction alpha-1 protein
Swissprots P17302 Q9Y5I8 Q6FHU1 B2R5U9
Accessions AAD37802 EAW48178 P17302 AK223289 BAD97009 AK294670 BAG57837 AK295460 BAG58393 AK297402 BAG59841 AK297761 BAG60109 AK297764 BAG60112 AK309377 AK309490 AK312324 BAG35246 AW664595 BC026329 AAH26329 BP226987 CR541660 CAG46461 DQ893649 ABM84575 DQ895611 ABM86537 M65188 AAA52131 X52947 CAA37122 NM_000165 NP_000156
Function Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:22411987}; Multi-pass membrane protein {ECO:0000269|PubMed:22411987}. Cell junction, gap junction {ECO:0000269|PubMed:22411987}.
Tissue Specificity Expressed in the heart and fetal cochlea. {ECO:0000269|PubMed:11741837}.
Top Pathways Gap junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Phospho-Connexin 43 (Ser368) Antibody - 3511 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS and C6 cells, untreated or PMA-treated, using Phospho-Connexin 43 (Ser368) Antibody.

Connexin 43 Antibody - 3512 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from untreated and PMA-treated C6, COS, HeLa and C2C12 cells using Connexin 43 Antibody.

connexin 43 (C-20) - sc-6560 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Connexin 43 (C-20):sc-6560. Western blot analysis of Connexin 43 expression in rat brain tissue extract.

connexin 43 (D-7) - sc-13558 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
connexin 43 (D-7): sc-13558. Western blot analysis of connexin 43 expression in mouse (A) and rat (B) brain tissue extracts.

connexin 43 (F-7) - sc-271837 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
connexin 43 (F-7): sc-271837. Western blot analysis of connexin 43 expression in non-transfected 293T: sc-117752 (A), human connexin 43 transfected 293T: sc-175002 (B) and C2C12 (C) whole cell lysates.

connexin 43 (H-150) - sc-9059 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
connexin 43 (H-150): sc-9059. Immunofluorescence staining of methanol-fixed SK-N-SH cells showing membrane localization.

connexin 43 (CXN-6) - sc-59949 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl ascites
Host Mouse
Clonality Monoclonal
connexin 43 (CXN-6): sc-59949. Western blot analysis of connexin 43 expression in non-transfected: sc-117752 (A) and mouse connexin 43 transfected: sc-119391 (B) 293T whole cell lysates and mouse brain tissue extract (C).

p-connexin 43 (hSer 262) - sc-17218 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-connexin 43 (Ser 279/282) - sc-12900 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of unphosphorylated (A,C,E) and human recombinant connexin 43 phosphorylated by rat recombinant ERK 2 (B,D,E). Antibodies tested include connexin 43 (H-150): sc-9059 (A,B), p-connexin 43 (Ser279/282)-R: sc-12900-R (C,D) and p-connexin 43 (Ser 255): sc-12899-R (E,F).

p-connexin 43 (Ser 368) - sc-25165 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-connexin 43 (Ser 368)-R: sc-25165-R. Western blot analysis of connexin 43 phosphorylation in mouse brain tissue extract.

p-connexin 43 (Ser 368) - sc-101660 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-connexin 43 (Ser 368): sc-101660. Western blot analysis of phosphorylated connexin 43 expression in untreated (A,B,C) and PMA-treated (D,E,F) HeLa (A,D), K-562 (B,E) and 293 (C,F) whole cell lysates.

p-connexin 43 (Tyr 265) - sc-17220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of connexin 43 phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) human heart tissue extracts. Antibodies tested include p-connexin 43 (Tyr 265)-R: sc-17220-R (A,B) and connexin 43 (C-20)-R: sc-6560-R (C,D).

Anti-Connexin 43 / GJA1 (phospho S261) antibody - ab62252 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62252 at 1/50 - 1/100 dilution staining Connexin 43 / GJA1 in Human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-Connexin 43 / GJA1 (phospho S265) antibody - ab193373 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Connexin 43 / GJA1 (phospho S265) antibody (ab193373) at 1/500 dilutionLane 1 : Extracts from HUVEC cellsLane 2 : Extracts from HUVEC cells with Antigen specific peptide

Anti-Connexin 43 / GJA1 (phospho S367) antibody - C-terminal - ab195764 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Connexin 43 / GJA1 (phospho S367) antibody - C-terminal (ab195764) at 1/500 dilutionLane 1 : PMA treated K562 whole cell lysates with antigen-specific peptideLane 2 : PMA treated K562 whole cell lysates

Anti-Connexin 43 / GJA1 (phospho S368) antibody - ab30559 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Connexin 43 / GJA1 (phospho S368) antibody (ab30559) at 1/1000 dilutionLane 1 : Rat hippocampal lysate Lane 2 : Rat hippocampal lysate (lambda phosphatase treated)Lysates/proteins at 10 µg per lane.

Anti-Connexin 43 / GJA1 (phospho S368) antibody - ab194928 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Connexin 43 / GJA1 (phospho S368) antibody (ab194928) at 1/500 dilutionLane 1 : As aboveLane 2 : As aboveSecondaryLane 1 : Untreated 293 cell lysateLane 2 : PMA treated 293 cell lysate

Anti-Connexin 43 / GJA1 antibody - ab66151 from Abcam

Prices $379.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
ab66151, at 1/50 dilution, staining Connexin 43 / GJA1 in human heart tissue by immunohistochemistry.

Anti-Connexin 43 / GJA1 antibody - ab62689 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62689 at 1/50 - 1/100 dilution staining Connexin 43 / GJA1 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-Connexin 43 / GJA1 antibody - ab65966 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Connexin 43 / GJA1 antibody (ab65966) at 2 µg/ml + Rat cardiac muscle tissue lysate at 30 µg

Anti-Connexin 43 / GJA1 antibody - ab15189 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab15189 staining GJA1 in human heart by Immunohistochemistry (FFPE-sections).

Anti-Connexin 43 / GJA1 antibody - ab47441 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Connexin 43 / GJA1 antibody (ab47441) at 1/500 dilutionLane 1 : Extracts from K562 cells, treated with PMA (200ng/ml, 10min). No peptide. Lane 2 : Extracts from K562 cells, treated with PMA (200ng/ml, 10min). Synthetic peptide present.

Anti-Connexin 43 / GJA1 antibody - ab52236 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Connexin 43 / GJA1 antibody (ab52236) at 1/300 dilutionLane 1 : A549 cell extract, untreated.Lane 2 : A549 cell extract, treated with the immunising peptide.

Anti-Connexin 43 / GJA1 antibody, prediluted - ab15190 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab15190 staining Connexin 43 / GJA1 in human heart tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin embedded tissue sections).

Anti-Connexin 43 / GJA1 antibody - N-terminal - ab135763 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Connexin 43 / GJA1 antibody - N-terminal (ab135763) at 1/100 dilution + CEM cell lysate at 35 µg
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