CDK4

Gene Symbol	CDK4
Entrez Gene	1019
Alt Symbol	CMM3, PSK-J3
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 4
Other Description	cell division protein kinase 4
Swissprots	Q6FG61 P11802 B4DNF9 O00576 B2R9A0
Accessions	AAC39521 AAC50506 AAD13991 AAM23014 CDI30203 CDM63717 EAW97058 EAW97059 EAW97060 EAW97061 EAW97062 P11802 AK297901 BAG60221 AK310724 AK313701 BAG36447 BC003644 AAH03644 BC005864 AAH05864 BC010153 AAH10153 BC015669 AAH15669 BI832658 BQ773564 CR407668 CAG28596 CR542247 CAG47043 DQ893137 ABM84063 DQ896420 ABM87419 M14505 AAA35673 U79269 AAB50213 Z48970 CAA88834 NM_000075 NP_000066 NM_052984
Function	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:9003781}.
Subcellular Location	Cytoplasm. Nucleus. Membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
Top Pathways	p53 signaling pathway, Tight junction, PI3K-Akt signaling pathway, T cell receptor signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CDK4 ELISA Kit (Sandwich ELISA) - LS-F4493 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.313-20 ng/ml

Human CDK4 ELISA Kit - abx151014 from Abbexa Category ELISA Kit Sensitivity 0.114 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human Cyclin-Dependent Kinase 4 ELISA Kit - abx053447 from Abbexa Category ELISA Kit Sensitivity 0.01 ng/ml Range 0.05 ng/ml - 4 ng/ml

Cyclin Dependent Kinase 4, CDK4, Human, ELISA Kit - E-EL-H2323 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Cyclin Dependent Kinase 4 (CDK4), Human, ELISA Kit - SEB233Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.121ng/mL Range 0.312-20ng/mL

Cyclin-dependent kinase 4, CDK-4, Human, ELISA Kit - CSB-E09174h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Cyclin-dependent kinase 4, CDK4, Human, ELISA Kit - E1233h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Cyclin Dependent Kinase 4, CDK4, Rabbit, ELISA Kit - E-EL-RB1079 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 4, CDK4, Chicken, ELISA Kit - E-EL-Ch2017 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cyclin Dependent Kinase 4, CDK4, Porcine, ELISA Kit - E-EL-P0824 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 4, CDK4, Guinea Pig, ELISA Kit - E-EL-GP0405 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cyclin Dependent Kinase 4, CDK4, Monkey, ELISA Kit - E-EL-MK1137 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human CDK-4 ELISA Kit - HC0730 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CDK-4 ELISA Kit - AC0730 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PACCase ELISA Kit - AP0593 from NeoScientific Category ELISA Kit Prices $300.00, $480.00 Sizes 100 µg, 200 µg

Human CDK4(Cyclin Dependent Kinase 4) ELISA Kit - E-EL-H2323 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Human CDK4 (Cyclin Dependent Kinase 4) CLIA Kit - E-CL-H1356 from Elabscience Category CLIA Kit Sensitivity 37.50 pg/mL Range Average Recovery (%)

CDK4, ELISA Kit - MBS2508040 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.875pg/mL Range 78.125-5000pg/mL

CDK4, ELISA Kit - MBS2514954 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CDK4, ELISA Kit - MBS2509096 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

CDK4, ELISA Kit - MBS2509614 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

CDK4, ELISA Kit - MBS2508870 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313--20ng/mL

CDK4, ELISA Kit - MBS2515158 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

Cyclin Dependent Kinase 4 (CDK-4), ELISA Kit - MBS263173 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin Dependent Kinase 4 (CDK-4), ELISA Kit - MBS265773 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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