CDK4

Gene Symbol	CDK4
Entrez Gene	1019
Alt Symbol	CMM3, PSK-J3
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 4
Other Description	cell division protein kinase 4
Swissprots	Q6FG61 P11802 B4DNF9 O00576 B2R9A0
Accessions	AAC39521 AAC50506 AAD13991 AAM23014 CDI30203 CDM63717 EAW97058 EAW97059 EAW97060 EAW97061 EAW97062 P11802 AK297901 BAG60221 AK310724 AK313701 BAG36447 BC003644 AAH03644 BC005864 AAH05864 BC010153 AAH10153 BC015669 AAH15669 BI832658 BQ773564 CR407668 CAG28596 CR542247 CAG47043 DQ893137 ABM84063 DQ896420 ABM87419 M14505 AAA35673 U79269 AAB50213 Z48970 CAA88834 NM_000075 NP_000066 NM_052984
Function	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:9003781}.
Subcellular Location	Cytoplasm. Nucleus. Membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
Top Pathways	p53 signaling pathway, Tight junction, PI3K-Akt signaling pathway, T cell receptor signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cdk4 peptide - ab8010 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Cdk4 full length protein - ab126909 from Abcam Category Protein Prices $235.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human Cdk4 full length protein - ab134542 from Abcam Category Protein Prices $297.00 Sizes 100 µg Source E. coli Species Human

Human Cdk4 full length protein - ab173025 from Abcam Category Protein Prices $147.00 Sizes 10 µg Source E. coli Species Human

Human Cdk4 full length protein - ab56281 from Abcam Category Protein Prices $188.00 Sizes 20 µg Source E. coli Species Human

Human Cdk4 full length protein - ab53662 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source E. coli Species Human

Human Cdk4 full length protein - ab169875 from Abcam Category Protein Prices $577.00 Sizes 50 µg Source E. coli Species Human

Human Cdk4 peptide - ab109075 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

CDK4 Antibody Blocking Peptide - LS-E3888 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK4 Antibody Blocking Peptide - LS-E10537 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK4 Antibody Blocking Peptide - LS-E10544 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK4 Antibody Blocking Peptide - LS-E9023 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK4 Recombinant Protein - H00001019-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CDK4 Recombinant Protein - H00001019-P03 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CDK4 Recombinant Protein - H00001019-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CDK4 Partial Recombinant Protein - H00001019-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CDK4 Protein - NBP2-22974 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

CDK4 Peptide - P2525 from Novus Biologicals Category Peptide Species Human

CDK4-Antibody-C-term-Blocking-Peptide - BP7520b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Cyclin-dependent kinase 4 (OPCA00933) - OPCA00933 from Aviva Systems Biology Category Protein Prices $198.00 Sizes 50 µg Species Human

CDK-4 Protein (OPPA01183) - OPPA01183 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Cyclin-Dependent Kinase 4 (Western Blot Control) Protein (OPRB00142) - OPRB00142 from Aviva Systems Biology Category Protein Prices $249.00 Sizes 10 µg

Cyclin-Dependent Kinase 4 Protein (OPRB00143) - OPRB00143 from Aviva Systems Biology Category Protein Prices $249.00 Sizes 10 µg

Cyclin-Dependent Kinase 4 Protein (OPRB00144) - OPRB00144 from Aviva Systems Biology Category Protein Prices $839.00 Sizes 100 µg

Human CDK4 CDK4 protein - orb245514 from Biorbyt Category Protein Prices $315.00, $502.00, $782.00, $1,139.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

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