CTLA4

Gene Symbol	CTLA4
Entrez Gene	1493
Alt Symbol	ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Species	Human
Gene Type	protein-coding
Description	cytotoxic T-lymphocyte-associated protein 4
Other Description	CD152 isoform|celiac disease 3|cytotoxic T lymphocyte associated antigen 4 short spliced form|cytotoxic T-lymphocyte protein 4|cytotoxic T-lymphocyte-associated serine esterase-4|insulin-dependent diabetes mellitus 12|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Swissprots	Q5S005 E9PDH0 Q9UKN9 Q53TD5 P16410 Q0PP65 O95653 Q8WXJ1 A0N1S0 Q96P43 Q52MC1
Accessions	AAA52127 AAF02499 AAK13084 AAL40932 AAX93176 ABC67470 ABG78999 ABG79000 ADV60197 ADV60198 ADV60199 ADV60200 CAY55959 EAW70354 P16410 AF414120 AAL07473 AF486806 AAL96664 AK313732 BAG36473 AY209009 AAO17066 AY792514 AAV66331 AY999702 AAY00166 BC069566 AAH69566 BC070162 AAH70162 BC074842 AAH74842 BC074893 AAH74893 BG058720 CD639535 DQ785106 ABG85285 L15006 AAB59385 U90273 AAD00698 XR_241294 NM_001037631 NP_001032720 NM_005214 NP_005205
Function	Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. {ECO:0000269|PubMed:16551244, ECO:0000269|PubMed:1714933}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18468488}; Single-pass type I membrane protein {ECO:0000269|PubMed:18468488}. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.
Tissue Specificity	Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. {ECO:0000269|PubMed:10493833, ECO:0000269|PubMed:16551244, ECO:0000269|PubMed:1713603}.
Top Pathways	T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Autoimmune thyroid disease, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CTLA4 / CD152 ELISA Kit (Sandwich ELISA) - LS-F4490 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 13.3 pg/ml Range 1.646-400 pg/ml

Mouse CTLA4 / CD152 ELISA Kit (Sandwich ELISA) - LS-F2645 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 1.646-400 pg/ml

Mouse CTLA4 / CD152 ELISA Kit (Sandwich ELISA) - LS-F230 from LifeSpan Bioscience Category ELISA Kit Prices $620.00, $1,090.00, $2,380.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 1.646 pg/ml Range 1.646-400 pg/ml

Human CTLA4 / CD152 ELISA Kit (Sandwich ELISA) - LS-F11241 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.78 Range 1.646-400 pg/ml

Mouse CTLA-4 DuoSet ELISA - DY476 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 125.00 - 8,000 pg/mL

Human sCTLA4 ELISA kit - 55R-IB49660 from Fitzgerald Category ELISA Kit Prices $825.00 Sizes 96 wells

Human CTLA-4 ELISA Kit - abx054735 from Abbexa Category ELISA Kit

Human CTLA4 ELISA Kit - abx151202 from Abbexa Category ELISA Kit Sensitivity 0.055 ng/ml Range 0.156 ng/ml - 10 ng/ml

Cytotoxic T Lymphocyte Associated Antigen 4, CTLA4, Human, ELISA Kit - E-EL-H2069 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Cytotoxic T lymphocyte associated antigen 4, CTLA-4, Human, ELISA Kit - CSB-E09171h from ARP American Research Products Category ELISA Kit Prices $450.00, $595.00, $596.00, $599.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 31.25 pg/ml Range 125 pg/ml-8000 pg/ml

Cytotoxic T-Lymphocyte Associated Antigen 4 (CTLA4), Human, ELISA Kit - SEB230Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.055ng/mL Range 0.156-10ng/mL

Cytotoxic T-lymphocyte protein 4, CTLA4, Human, ELISA Kit - E1230h from ARP American Research Products Category ELISA Kit Prices $576.00 Sizes 96 t Range 0.78-50 ng/mL

Cytotoxic T-Lymphocyte Associated Antigen 4, CTLA4, Mouse, ELISA Kit - E-EL-M0398 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 75 Range 125-8000pg/mL

Cytotoxic T-Lymphocyte Associated Antigen 4, CTLA4, Rat, ELISA Kit - E-EL-R0314 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Cytotoxic T Lymphocyte Associated Antigen 4, CTLA4, Rabbit, ELISA Kit - E-EL-RB0512 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cytotoxic T Lymphocyte Associated Antigen 4, CTLA4, Chicken, ELISA Kit - E-EL-Ch1122 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cytotoxic T Lymphocyte Associated Antigen 4, CTLA4, Porcine, ELISA Kit - E-EL-P0070 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cytotoxic T Lymphocyte Associated Antigen 4, CTLA4, Sheep, ELISA Kit - E-EL-S0641 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Cytotoxic T Lymphocyte Associated Antigen 4, CTLA4, Guinea Pig, ELISA Kit - E-EL-GP0530 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cytotoxic T Lymphocyte Associated Antigen 4, CTLA4, Monkey, ELISA Kit - E-EL-MK1284 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

CTLA4 (Human) Matched Antibody Pair - H00001493-AP41 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human sCD152/CTLA-4 ELISA kit - KA0165 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

LEGEND MAX™ Human Soluble CTLA-4 ELISA Kit with Pre-coated Plates - 437407 from Biolegend Category ELISA Kit Prices $395.00, $1,395.00 Sizes 1 pre-coated plate, 5 pre-coated plates Sensitivity 17 pg/mL Range 39-2,500 pg/mL

Human CTLA4 ELISA Kit - HC0635 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human CD ELISA Kit - HC0084 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

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