CTLA4

Gene Symbol CTLA4
Entrez Gene 1493
Alt Symbol ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Species Human
Gene Type protein-coding
Description cytotoxic T-lymphocyte-associated protein 4
Other Description CD152 isoform|celiac disease 3|cytotoxic T lymphocyte associated antigen 4 short spliced form|cytotoxic T-lymphocyte protein 4|cytotoxic T-lymphocyte-associated serine esterase-4|insulin-dependent diabetes mellitus 12|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Swissprots Q5S005 E9PDH0 Q9UKN9 Q53TD5 P16410 Q0PP65 O95653 Q8WXJ1 A0N1S0 Q96P43 Q52MC1
Accessions AAA52127 AAF02499 AAK13084 AAL40932 AAX93176 ABC67470 ABG78999 ABG79000 ADV60197 ADV60198 ADV60199 ADV60200 CAY55959 EAW70354 P16410 AF414120 AAL07473 AF486806 AAL96664 AK313732 BAG36473 AY209009 AAO17066 AY792514 AAV66331 AY999702 AAY00166 BC069566 AAH69566 BC070162 AAH70162 BC074842 AAH74842 BC074893 AAH74893 BG058720 CD639535 DQ785106 ABG85285 L15006 AAB59385 U90273 AAD00698 XR_241294 NM_001037631 NP_001032720 NM_005214 NP_005205
Function Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. {ECO:0000269|PubMed:16551244, ECO:0000269|PubMed:1714933}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:18468488}; Single-pass type I membrane protein {ECO:0000269|PubMed:18468488}. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.
Tissue Specificity Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. {ECO:0000269|PubMed:10493833, ECO:0000269|PubMed:16551244, ECO:0000269|PubMed:1713603}.
Top Pathways T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Autoimmune thyroid disease, Rheumatoid arthritis

CTLA-4 CRISPR/Cas9 KO Plasmid (h) - sc-400948 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTLA-4 HDR Plasmid (h) - sc-400948-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTLA-4 Double Nickase Plasmid (h) - sc-400948-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTLA-4 Double Nickase Plasmid (h2) - sc-400948-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTLA-4 CRISPR Activation Plasmid (h) - sc-400948-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTLA-4 CRISPR Activation Plasmid (h2) - sc-400948-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTLA-4 Lentiviral Activation Particles (h) - sc-400948-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTLA-4 Lentiviral Activation Particles (h2) - sc-400948-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CTLA-4 siRNA (h) - sc-42766 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CTLA-4 shRNA Plasmid (h) - sc-42766-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CTLA-4 shRNA (h) Lentiviral Particles - sc-42766-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CTLA-4 RNAi - H00001493-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CTLA-4 RNAi - H00001493-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CTLA-4 RNAi - H00001493-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CTLA-4 RNAi - H00001493-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU124981 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1878 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1878 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08643 from Sigma-Aldrich

Category miRNA

CTLA4 siRNA (Human) - CRH1056 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CTLA-4 RNAi - H00001493-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CTLA4 - MBS8201632 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CTLA4 (NM_005214.4) - SHH271253 from Creative biogene

Category siRNA
Species Reactivities Human

Human CTLA4 siRNA - orb261558 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CTLA4 shRNA Plasmid (Human) - CHH1056 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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