CTLA4

Gene Symbol	CTLA4
Entrez Gene	1493
Alt Symbol	ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Species	Human
Gene Type	protein-coding
Description	cytotoxic T-lymphocyte-associated protein 4
Other Description	CD152 isoform|celiac disease 3|cytotoxic T lymphocyte associated antigen 4 short spliced form|cytotoxic T-lymphocyte protein 4|cytotoxic T-lymphocyte-associated serine esterase-4|insulin-dependent diabetes mellitus 12|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Swissprots	Q5S005 E9PDH0 Q9UKN9 Q53TD5 P16410 Q0PP65 O95653 Q8WXJ1 A0N1S0 Q96P43 Q52MC1
Accessions	AAA52127 AAF02499 AAK13084 AAL40932 AAX93176 ABC67470 ABG78999 ABG79000 ADV60197 ADV60198 ADV60199 ADV60200 CAY55959 EAW70354 P16410 AF414120 AAL07473 AF486806 AAL96664 AK313732 BAG36473 AY209009 AAO17066 AY792514 AAV66331 AY999702 AAY00166 BC069566 AAH69566 BC070162 AAH70162 BC074842 AAH74842 BC074893 AAH74893 BG058720 CD639535 DQ785106 ABG85285 L15006 AAB59385 U90273 AAD00698 XR_241294 NM_001037631 NP_001032720 NM_005214 NP_005205
Function	Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. {ECO:0000269|PubMed:16551244, ECO:0000269|PubMed:1714933}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18468488}; Single-pass type I membrane protein {ECO:0000269|PubMed:18468488}. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.
Tissue Specificity	Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. {ECO:0000269|PubMed:10493833, ECO:0000269|PubMed:16551244, ECO:0000269|PubMed:1713603}.
Top Pathways	T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Autoimmune thyroid disease, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CTLA4 protein fragment - ab180054 from Abcam Category Protein Prices $286.00 Sizes 200 µg Source HEK 293 cells Species Human

Human CTLA4 protein fragment - ab167727 from Abcam Category Protein Source HEK 293 cells Species Human

Human CTLA4 protein fragment - ab140054 from Abcam Category Protein Source E. coli Species Human

Human CTLA4 protein fragment - ab198420 from Abcam Category Protein Source HEK 293 cells Species Human

Human CTLA4 protein fragment - ab169909 from Abcam Category Protein Source E. coli Species Human

Human CTLA4 protein fragment - ab173526 from Abcam Category Protein Source E. coli Species Human

Mouse CTLA4 protein fragment - ab59654 from Abcam Category Protein Source NS.1 cells Species Mouse

CTLA4 / CD152 Antibody Blocking Peptide - LS-E229 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CTLA4 / CD152 Antibody Blocking Peptide - LS-E10140 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CTLA-4 Partial Recombinant Protein - H00001493-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CTLA-4 Protein - NBP2-22987 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

CTLA-4 Recombinant Protein - P4933 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 25 µg Species Human

CTLA4-Antibody-N-term-Blocking-peptide - BP10465a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CTLA4-Antibody-C-term-Blocking-Peptide - BP9453b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NOD2 (Internal) blocking peptide - GTX89233-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Recombinant Human CTLA-4 Fc Chimera - 325-CT-200 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Recombinant Human CTLA-4 Fc Chimera, CF - 325-CT-200/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Recombinant Mouse CTLA-4 Fc Chimera - 434-CT-200 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse CTLA-4 Fc Chimera, CF - 434-CT-200/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human CTLA-4 Fc Chimera, CF (CHO-expressed) - 7268-CT-100 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

CTLA 4 Protein (OPPA00629) - OPPA00629 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Sf9 Insect Cells

CTLA4 Proteins - orb232685 from Biorbyt Category Protein Prices $417.00, $570.00 Sizes 100 μg, 200 μg

Human CTLA4 protein - orb80294 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

Canine CTLA-4 (Fc Tag) protein - orb232684 from Biorbyt Category Protein Prices $323.00, $434.00 Sizes 100 μg, 200 μg

CTLA-4 peptide - orb72575 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

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