NEDD8

Gene Symbol	NEDD8
Entrez Gene	4738
Alt Symbol	NEDD-8
Species	Human
Gene Type	protein-coding
Description	neural precursor cell expressed, developmentally down-regulated 8
Other Description	neddylin|ubiquitin-like protein Nedd8
Swissprots	Q6LES6 Q3SXN8 Q15843
Accessions	CDM22114 Q15843 AK125214 BC038290 BC064899 BC104200 AAI04201 BC104201 AAI04202 BC104664 AAI04665 BE548741 CF130271 CR407662 CAG28590 D23662 BAA04889 NM_006156 NP_006147
Function	Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. {ECO:0000269|PubMed:10318914, ECO:0000269|PubMed:10597293, ECO:0000269|PubMed:11953428}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:9353319}. Note=Mainly nuclear.
Tissue Specificity	Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269|PubMed:10597293, ECO:0000269|PubMed:9353319}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat NEDD8 ELISA Kit (Cell-Based ELISA) - LS-F2180 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

NEDD8 Conjugation Initiation Kit - K-800 from R&D Systems Prices $395.00 Sizes 1 kit

NEDD8 Conjugation Reaction Buffer Kit - SK-20 from R&D Systems Prices $59.00 Sizes 1 kit

NEDD8 (NEDD8), Human, ELISA Kit - CSB-EL015684HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

neural precursor cell expressed, developmentally down-regulated 8, ELISA Kit - MBS936702 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human NEDD8 is typically less than 9.77 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 39.07 pg/ml-2500 pg/ml.

NEDD8 Colorimetric Cell-Based ELISA Kit - CB5482 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human NEDD8(NEDD8) ELISA kit - CSB-EL015684HU from Cusabio Category ELISA Kit Sensitivity 9.77 pg/ml Range Request Information

NEDD8 ELISA Kit - DEIA-XYA1308 from Creative Diagnostics Category ELISA Kit

Human NEDD8(NEDD8) ELISA Kit - EKC34747 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity Request Information Range Request Information

Human NEDD8 ELISA Kit - E026049 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human NEDD8 is typically less than 9.77 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

NEDD8 Colorimetric Cell-Based ELISA Kit - EKA50415 from Biomatik Category ELISA Kit Prices $399.00 Sizes 96 tests Sensitivity At least 5000 cells/well Range Qualitative

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