NEDD8

Gene Symbol	NEDD8
Entrez Gene	4738
Alt Symbol	NEDD-8
Species	Human
Gene Type	protein-coding
Description	neural precursor cell expressed, developmentally down-regulated 8
Other Description	neddylin|ubiquitin-like protein Nedd8
Swissprots	Q6LES6 Q3SXN8 Q15843
Accessions	CDM22114 Q15843 AK125214 BC038290 BC064899 BC104200 AAI04201 BC104201 AAI04202 BC104664 AAI04665 BE548741 CF130271 CR407662 CAG28590 D23662 BAA04889 NM_006156 NP_006147
Function	Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. {ECO:0000269|PubMed:10318914, ECO:0000269|PubMed:10597293, ECO:0000269|PubMed:11953428}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:9353319}. Note=Mainly nuclear.
Tissue Specificity	Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269|PubMed:10597293, ECO:0000269|PubMed:9353319}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human NEDD8 full length protein - ab125816 from Abcam Category Protein Source E. coli Species Human

Active human NEDD8 full length protein - ab189673 from Abcam Category Protein Prices $572.00 Sizes 25 µg Source E. coli Species Human

Active human NEDD8 full length protein - ab190019 from Abcam Category Protein Prices $342.00 Sizes 500 µg Source E. coli Species Human

Active human NEDD8 full length protein - ab190327 from Abcam Category Protein Prices $572.00 Sizes 50 µg Source E. coli Species Human

Active human NEDD8 full length protein - ab190424 from Abcam Category Protein Prices $461.00 Sizes 50 µg Source E. coli Species Human

Active human NEDD8 full length protein - ab190042 from Abcam Category Protein Prices $342.00 Sizes 500 µl Source E. coli Species Human

Human NEDD8 full length protein - ab190449 from Abcam Category Protein Source E. coli Species Human

Human NEDD8 full length protein - ab190448 from Abcam Category Protein Source E. coli Species Human

Human NEDD8 full length protein - ab190455 from Abcam Category Protein Source E. coli Species Human

Human NEDD8 full length protein - ab87008 from Abcam Category Protein Source E. coli Species Human

Human NEDD8 full length protein - ab117668 from Abcam Category Protein Source E. coli Species Human

NEDD8 Antibody Blocking Peptide - LS-E1536 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEDD8 Partial Recombinant Protein - H00004738-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

NEDD8 Recombinant Protein - H00004738-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NEDD8 Protein - NBC1-19068 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

Recombinant Human NEDD8 Protein - NBP1-99542 from Novus Biologicals Category Protein Prices $235.00 Sizes 25 µg Species Human

NEDD8 Peptide - P0290 from Novus Biologicals Category Peptide Species Human

NEDD8-Antibody-N-term-Blocking-Peptide - BP1226a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NEDD8 Protein - GTX116090-pro from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Human

Recombinant Human NEDD8, CF - UL-812-500 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human NEDD8 Fluorescein, CF - UL-830-050 from R&D Systems Category Protein

Recombinant Human NEDD8 AMC, CF - UL-552-050 from R&D Systems Category Protein

Recombinant Human NEDD8 Aldehyde, CF - UL-801-050 from R&D Systems Category Protein

Recombinant Human His6-NEDD8, CF - UL-813-500 from R&D Systems Category Protein

Recombinant Human FLAG-NEDD8 Vinyl Sulfone, CF - UL-803-025 from R&D Systems Category Protein

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