| Gene Symbol |
Frzb
|
| Entrez Gene |
20378
|
| Alt Symbol |
Frp, Sfrp3, frezzled, fritz, frzb-1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
frizzled-related protein
|
| Other Description |
frizzled-related protein 1|sFRP-3|secreted frizzled-related protein 3|secreted frizzled-related sequence protein 3
|
| Swissprots |
P97401 O09093 O09075 Q91W58
|
| Accessions |
EDL27262 P97401 AK019093 BAB31542 AK029941 BAC26690 AK184854 BC016884 AAH16884 U68058 AAC53135 U88568 AAC53147 U91905 AAB51300 NM_011356 NP_035486
|
| Function |
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
| Tissue Specificity |
Expressed in kidney, brain, testis. Weak expression in spleen and heart. {ECO:0000269|PubMed:9096311, ECO:0000269|PubMed:9178261}.
|
