Gene Symbol | Frzb |
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Entrez Gene | 20378 |
Alt Symbol | Frp, Sfrp3, frezzled, fritz, frzb-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | frizzled-related protein |
Other Description | frizzled-related protein 1|sFRP-3|secreted frizzled-related protein 3|secreted frizzled-related sequence protein 3 |
Swissprots | P97401 O09093 O09075 Q91W58 |
Accessions | EDL27262 P97401 AK019093 BAB31542 AK029941 BAC26690 AK184854 BC016884 AAH16884 U68058 AAC53135 U88568 AAC53147 U91905 AAB51300 NM_011356 NP_035486 |
Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted {ECO:0000305}. |
Tissue Specificity | Expressed in kidney, brain, testis. Weak expression in spleen and heart. {ECO:0000269|PubMed:9096311, ECO:0000269|PubMed:9178261}. |
FRP-3 CRISPR/Cas9 KO Plasmid (m) - sc-422898 from Santa Cruz Biotechnology
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FRP-3 HDR Plasmid (m) - sc-422898-HDR from Santa Cruz Biotechnology
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FRP-3 Double Nickase Plasmid (m) - sc-422898-NIC from Santa Cruz Biotechnology
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FRP-3 Double Nickase Plasmid (m2) - sc-422898-NIC-2 from Santa Cruz Biotechnology
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FRP-3 CRISPR Activation Plasmid (m) - sc-422898-ACT from Santa Cruz Biotechnology
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FRP-3 CRISPR Activation Plasmid (m2) - sc-422898-ACT-2 from Santa Cruz Biotechnology
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FRP-3 Lentiviral Activation Particles (m) - sc-422898-LAC from Santa Cruz Biotechnology
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FRP-3 Lentiviral Activation Particles (m2) - sc-422898-LAC-2 from Santa Cruz Biotechnology
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FRP-3 siRNA (m) - sc-35412 from Santa Cruz Biotechnology
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FRP-3 shRNA Plasmid (m) - sc-35412-SH from Santa Cruz Biotechnology
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FRP-3 shRNA (m) Lentiviral Particles - sc-35412-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU087951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31565 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31565 from Sigma-Aldrich
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FRZB siRNA (Mouse) - CRM3682 from Cohesion Biosciences
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FRZB - MBS828045 from MyBioSource
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shRNA set against Mouse FRZB (NM_011356.4) - SHH297293 from Creative biogene
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shRNA set against Mouse Frzb(NM_011356.4) - SHH068679 from Creative biogene
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Mouse FRZB siRNA - orb283158 from Biorbyt
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FRZB shRNA Plasmid (Mouse) - CHM3682 from Cohesion Biosciences
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FRZB miRNA 3'UTR clone - MiUTR1M-04808 from Creative biogene
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