Gene Symbol | Frzb |
---|---|
Entrez Gene | 20378 |
Alt Symbol | Frp, Sfrp3, frezzled, fritz, frzb-1 |
Species | Mouse |
Gene Type | protein-coding |
Description | frizzled-related protein |
Other Description | frizzled-related protein 1|sFRP-3|secreted frizzled-related protein 3|secreted frizzled-related sequence protein 3 |
Swissprots | P97401 O09093 O09075 Q91W58 |
Accessions | EDL27262 P97401 AK019093 BAB31542 AK029941 BAC26690 AK184854 BC016884 AAH16884 U68058 AAC53135 U88568 AAC53147 U91905 AAB51300 NM_011356 NP_035486 |
Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted {ECO:0000305}. |
Tissue Specificity | Expressed in kidney, brain, testis. Weak expression in spleen and heart. {ECO:0000269|PubMed:9096311, ECO:0000269|PubMed:9178261}. |