SERPINA1

Gene Symbol	SERPINA1
Entrez Gene	5265
Alt Symbol	A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT
Species	Human
Gene Type	protein-coding
Description	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Other Description	alpha-1 protease inhibitor|alpha-1-antiproteinase|alpha-1-antitrypsin|alpha-1-antitrypsin null|protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin|serine (or cysteine) proteinase inhibitor, clade A, member 1|serpin A1
Swissprots	Q9UCM3 Q96BF9 A6PX14 B2RDQ8 Q9P1P0 Q5U0M1 P01009 Q86U18 Q7M4R2 Q53XB8 Q86U19 Q96ES1 Q13672 Q9UCE6 Q0PVP5
Accessions	AAA51547 AAB59369 AAB59370 AAB59371 AAB59495 AAF15128 AAP13998 ABA41642 ABC62080 ABR29795 ABS30840 ABS30841 ACB47283 ACR55079 CAJ15161 EAW81570 EAW81571 EAW81572 EAW81573 EAW81574 EAW81575 EAW81576 P01009 AA317159 AF119873 AAF69627 AK026174 AK315637 BAG38005 BC011991 AAH11991 BC015642 AAH15642 BC070163 BG483969 BM844817 BM923322 BP296710 BP300943 BP301274 BT019455 AAV38262 BX161449 CAD61914 BX247968 CAD62306 BX248002 CAD62334 BX248257 CAD62585 BX477352 CD685665 DA427262 DA428299 DA433050 DA433058 DA672472 DA675981 DA966896 DQ682455 ABG73380 FJ830375 ACO55054 GU727620 ADU87622 HQ448245 ADQ32725 K01396 AAB59375 M11465 AAA51546 M26123 AAA51545 V00496 CAA23755 X01683 CAA25838 X02920 CAA26677 X05826 CAA29267 X05827 X17122 CAA34982 NM_000295 NP_000286 NM_001002235 NP_001002235 NM_001002236 NP_001002236 NM_001127700 NP_001121172 NM_001127701 NP_001121173 NM_001127702 NP_001121174 NM_001127703 NP_001121175 NM_001127704 NP_001121176 NM_001127705 NP_001121177 NM_001127706 NP_001121178 NM_001127707 NP_001121179
Function	Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Subcellular Location	Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.
Tissue Specificity	Ubiquitous. Expressed in leukocytes and plasma. {ECO:0000269|PubMed:23826168}.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SERPINA1 293 Cell Lysate - 400197 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SERPINA1 293 Cell Lysate - 410027 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SERPINA1 293 Cell Lysate - 410028 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Serpin A1/alpha 1-Antitrypsin Overexpression Lysate (Native) - NBL1-15833 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Serpin A1/alpha 1-Antitrypsin Overexpression Lysate (Native) - NBL1-15834 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Serpin A1/alpha 1-Antitrypsin Overexpression Lysate (Native) - NBL1-15835 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

AAT (h): 293 Lysate - sc-112989 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SERPINA1 Over-expression Lysate Product - GWB-AFAF41 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

SERPINA1 Over-expression Lysate Product - GWB-6DBC42 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

SERPINA1 Over-expression Lysate Product - GWB-47E545 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human SerpinA1 / A1AT HEK293 Cell Lysate (WB positive control) - 10306-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Alpha-1-Antitrypsin Deficient Plasma (EDTA) - D500104 from AssayPro Category Blood Product Prices $40.00 Sizes 1 ml Species Human Tissue Plasma

Human Alpha-1-Antitrypsin Deficient Plasma (EDTA) - D500105 from AssayPro Category Blood Product Prices $200.00 Sizes 10 ml Species Human Tissue Plasma

Human Alpha-1-Antitrypsin Deficient Plasma (EDTA) - D500106 from AssayPro Category Blood Product Prices $1,600.00 Sizes 100 ml (10 vials x 10 ml) Species Human Tissue Plasma

Human Alpha-1-Antitrypsin Deficient Plasma (Heparin) - D500107 from AssayPro Category Blood Product Prices $40.00 Sizes 1 ml Species Human Tissue Plasma

Human Alpha-1-Antitrypsin Deficient Plasma (Heparin) - D500108 from AssayPro Category Blood Product Prices $200.00 Sizes 10 ml Species Human Tissue Plasma

Human Alpha-1-Antitrypsin Deficient Plasma (Heparin) - D500109 from AssayPro Category Blood Product Prices $1,600.00 Sizes 100 ml (10 vials x 10 ml) Species Human Tissue Plasma

Human Alpha-1-Antitrypsin Deficient Plasma (Sodium Citrate) - D500101 from AssayPro Category Blood Product Prices $40.00 Sizes 1 ml Species Human Tissue Plasma

Human Alpha-1-Antitrypsin Deficient Plasma (Sodium Citrate) - D500102 from AssayPro Category Blood Product Prices $200.00 Sizes 10 ml Species Human Tissue Plasma

Human Alpha-1-Antitrypsin Deficient Plasma (Sodium Citrate) - D500103 from AssayPro Category Blood Product Prices $1,600.00 Sizes 100 ml (10 vials x 10 ml) Species Human Tissue Plasma

Human Alpha-1-Antitrypsin Deficient Serum - D500110 from AssayPro Category Blood Product Prices $40.00 Sizes 1 ml Species Human Tissue Serum

Human Alpha-1-Antitrypsin Deficient Serum - D500111 from AssayPro Category Blood Product Prices $200.00 Sizes 10 ml Species Human Tissue Serum

Human Alpha-1-Antitrypsin Deficient Serum - D500112 from AssayPro Category Blood Product Prices $1,600.00 Sizes 100 ml (10 vials x 10 ml) Species Human Tissue Serum

Serpin A1/alpha 1-Antitrypsin Overexpression Lysate (Native) - NBP2-11136 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Serpin A1/alpha 1-Antitrypsin Overexpression Lysate (Native) - NBP2-11135 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

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