SERPINA1

Gene Symbol SERPINA1
Entrez Gene 5265
Alt Symbol A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT
Species Human
Gene Type protein-coding
Description serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Other Description alpha-1 protease inhibitor|alpha-1-antiproteinase|alpha-1-antitrypsin|alpha-1-antitrypsin null|protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin|serine (or cysteine) proteinase inhibitor, clade A, member 1|serpin A1
Swissprots Q9UCM3 Q96BF9 A6PX14 B2RDQ8 Q9P1P0 Q5U0M1 P01009 Q86U18 Q7M4R2 Q53XB8 Q86U19 Q96ES1 Q13672 Q9UCE6 Q0PVP5
Accessions AAA51547 AAB59369 AAB59370 AAB59371 AAB59495 AAF15128 AAP13998 ABA41642 ABC62080 ABR29795 ABS30840 ABS30841 ACB47283 ACR55079 CAJ15161 EAW81570 EAW81571 EAW81572 EAW81573 EAW81574 EAW81575 EAW81576 P01009 AA317159 AF119873 AAF69627 AK026174 AK315637 BAG38005 BC011991 AAH11991 BC015642 AAH15642 BC070163 BG483969 BM844817 BM923322 BP296710 BP300943 BP301274 BT019455 AAV38262 BX161449 CAD61914 BX247968 CAD62306 BX248002 CAD62334 BX248257 CAD62585 BX477352 CD685665 DA427262 DA428299 DA433050 DA433058 DA672472 DA675981 DA966896 DQ682455 ABG73380 FJ830375 ACO55054 GU727620 ADU87622 HQ448245 ADQ32725 K01396 AAB59375 M11465 AAA51546 M26123 AAA51545 V00496 CAA23755 X01683 CAA25838 X02920 CAA26677 X05826 CAA29267 X05827 X17122 CAA34982 NM_000295 NP_000286 NM_001002235 NP_001002235 NM_001002236 NP_001002236 NM_001127700 NP_001121172 NM_001127701 NP_001121173 NM_001127702 NP_001121174 NM_001127703 NP_001121175 NM_001127704 NP_001121176 NM_001127705 NP_001121177 NM_001127706 NP_001121178 NM_001127707 NP_001121179
Function Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Subcellular Location Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.
Tissue Specificity Ubiquitous. Expressed in leukocytes and plasma. {ECO:0000269|PubMed:23826168}.
Top Pathways Complement and coagulation cascades

AAT CRISPR/Cas9 KO Plasmid (h) - sc-401034 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AAT HDR Plasmid (h) - sc-401034-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AAT Double Nickase Plasmid (h) - sc-401034-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AAT Double Nickase Plasmid (h2) - sc-401034-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AAT CRISPR Activation Plasmid (h) - sc-401034-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AAT CRISPR Activation Plasmid (h2) - sc-401034-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AAT Lentiviral Activation Particles (h) - sc-401034-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AAT Lentiviral Activation Particles (h2) - sc-401034-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AAT siRNA (h) - sc-40945 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AAT shRNA Plasmid (h) - sc-40945-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AAT shRNA (h) Lentiviral Particles - sc-40945-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU112361 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU090971 from Sigma-Aldrich

Category siRNA

MISSION® esiRNA - EHU017931 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19129 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19129 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SERPINA1 siRNA (Human) - CRH3514 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SERPINA1 - MBS8238547 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SERPINA1 (NM_000295.4) - SHH404880 from Creative biogene

Category siRNA
Species Reactivities Human

Human alpha 1 Antitrypsin siRNA - orb264016 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SERPINA1 shRNA Plasmid (Human) - CHH3514 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SERPINA1 miRNA 3'UTR clone - MiUTR3H-00164 from Creative biogene

Species Reactivities Human

SERPINA1 miRNA 3'UTR clone - MiUTR3H-00165 from Creative biogene

Species Reactivities Human

SERPINA1 miRNA 3'UTR clone - MiUTR3H-00166 from Creative biogene

Species Reactivities Human

SERPINA1 miRNA 3'UTR clone - MiUTR3H-00167 from Creative biogene

Species Reactivities Human
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