SERPINA1

Gene Symbol	SERPINA1
Entrez Gene	5265
Alt Symbol	A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT
Species	Human
Gene Type	protein-coding
Description	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Other Description	alpha-1 protease inhibitor|alpha-1-antiproteinase|alpha-1-antitrypsin|alpha-1-antitrypsin null|protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin|serine (or cysteine) proteinase inhibitor, clade A, member 1|serpin A1
Swissprots	Q9UCM3 Q96BF9 A6PX14 B2RDQ8 Q9P1P0 Q5U0M1 P01009 Q86U18 Q7M4R2 Q53XB8 Q86U19 Q96ES1 Q13672 Q9UCE6 Q0PVP5
Accessions	AAA51547 AAB59369 AAB59370 AAB59371 AAB59495 AAF15128 AAP13998 ABA41642 ABC62080 ABR29795 ABS30840 ABS30841 ACB47283 ACR55079 CAJ15161 EAW81570 EAW81571 EAW81572 EAW81573 EAW81574 EAW81575 EAW81576 P01009 AA317159 AF119873 AAF69627 AK026174 AK315637 BAG38005 BC011991 AAH11991 BC015642 AAH15642 BC070163 BG483969 BM844817 BM923322 BP296710 BP300943 BP301274 BT019455 AAV38262 BX161449 CAD61914 BX247968 CAD62306 BX248002 CAD62334 BX248257 CAD62585 BX477352 CD685665 DA427262 DA428299 DA433050 DA433058 DA672472 DA675981 DA966896 DQ682455 ABG73380 FJ830375 ACO55054 GU727620 ADU87622 HQ448245 ADQ32725 K01396 AAB59375 M11465 AAA51546 M26123 AAA51545 V00496 CAA23755 X01683 CAA25838 X02920 CAA26677 X05826 CAA29267 X05827 X17122 CAA34982 NM_000295 NP_000286 NM_001002235 NP_001002235 NM_001002236 NP_001002236 NM_001127700 NP_001121172 NM_001127701 NP_001121173 NM_001127702 NP_001121174 NM_001127703 NP_001121175 NM_001127704 NP_001121176 NM_001127705 NP_001121177 NM_001127706 NP_001121178 NM_001127707 NP_001121179
Function	Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Subcellular Location	Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.
Tissue Specificity	Ubiquitous. Expressed in leukocytes and plasma. {ECO:0000269|PubMed:23826168}.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human alpha 1 Antitrypsin full length protein - ab91136 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Human

Human alpha 1 Antitrypsin full length protein - ab167788 from Abcam Category Protein Prices $285.00 Sizes 1 mg Source Native Species Human

Human alpha 1 Antitrypsin full length protein - ab77937 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Human

Human alpha 1 Antitrypsin full length protein - ab79181 from Abcam Category Protein Prices $228.00, $866.00 Sizes 100 µg, 500 µg Source E. coli Species Human

SERPINA1 / Alpha 1 Antitrypsin Antibody Blocking Peptide - LS-E10570 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SERPINA1 / Alpha 1 Antitrypsin Antibody Blocking Peptide - LS-E21665 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SERPINA1 / Alpha 1 Antitrypsin Antibody Blocking Peptide - LS-E10127 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Serpin A1/alpha 1-Antitrypsin Protein - H00005265-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Serpin A1/alpha 1-Antitrypsin Recombinant Protein - H00005265-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Serpin A1/alpha 1-Antitrypsin Protein - NBC1-18549 from Novus Biologicals Category Protein Prices $329.00 Sizes 100 µg Source E.coli Species Human

Serpin A1/alpha 1-Antitrypsin Protein - NBP2-34832 from Novus Biologicals Category Protein Prices $849.00 Sizes 10 mg

Serpin A1/alpha 1-Antitrypsin Protein - P4948 from Novus Biologicals Category Protein Prices $449.00 Sizes 1 mg Species Human

SERPINA1-Antibody-Center-Blocking-Peptide - BP9431d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SERPINA1-Antibody-N-term-Blocking-Peptide - BP9431a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Serpin A1/alpha-1-Antitrypsin, CF - 1268-PI-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Glu25-Lys418, with a C-terminal 10-His tag

Human Alpha 1-Antitrypsin Protein (OPMA04238) - OPMA04238 from Aviva Systems Biology Category Protein Prices $135.00 Sizes 1 mg Source Human Plasma Species Human

SERPINA1 Protein (OPPA02233) - OPPA02233 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human alpha 1 Antitrypsin protein - orb169276 from Biorbyt Category Protein Prices $230.00, $442.00, $1,590.00 Sizes 20 μg, 100 μg, 1 mg Source Rice Grain (Oryza Sativa). Species Human

Human Alpha 1-Antitrypsin protein - orb82117 from Biorbyt Category Protein Prices $238.00 Sizes 1 mg Source Sample obtained from Human Plasma. Species Human

Human SerpinA1 His tag protein - orb83114 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Human Species Human

Rat Serpina1 protein - orb246435 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Rat

Human SERPINA1 protein - orb246917 from Biorbyt Category Protein Prices $502.00, $774.00, $1,054.00 Sizes 20 μg, 50 μg, 100 μg Species Human

Rat Serpina1 protein - orb245985 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Rat

Human Alpha-1 Antitrypsin protein - orb81355 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli

alpha 1 Antitrypsin protein - 30-AA23 from Fitzgerald Category Protein Prices $175.00 Sizes 1 mg

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