| Gene Symbol |
Mocs3
|
| Entrez Gene |
69372
|
| Alt Symbol |
1700020H17Rik, Uba4
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
molybdenum cofactor synthesis 3
|
| Other Description |
MPT synthase sulfurylase|adenylyltransferase and sulfurtransferase MOCS3|molybdopterin synthase sulfurylase
|
| Swissprots |
A2BDX3
|
| Accessions |
A2BDX3 EDL06550 AK006163 BC115985 AAI15986 BE133066 BE333092 BG083535 BY727851 NM_001160330 NP_001153802
|
| Function |
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. {ECO:0000255|HAMAP-Rule:MF_03049}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03049}.
|
| Top Pathways |
Sulfur relay system
|