| Gene Symbol | Mocs3 |
|---|---|
| Entrez Gene | 69372 |
| Alt Symbol | 1700020H17Rik, Uba4 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | molybdenum cofactor synthesis 3 |
| Other Description | MPT synthase sulfurylase|adenylyltransferase and sulfurtransferase MOCS3|molybdopterin synthase sulfurylase |
| Swissprots | A2BDX3 |
| Accessions | A2BDX3 EDL06550 AK006163 BC115985 AAI15986 BE133066 BE333092 BG083535 BY727851 NM_001160330 NP_001153802 |
| Function | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. {ECO:0000255|HAMAP-Rule:MF_03049}. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03049}. |
| Top Pathways | Sulfur relay system |
Recombinant Mouse Mocs3, His-tagged - Mocs3-3194M from Creative Biomart
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Recombinant Mouse Adenylyltransferase and sulfurtransferase MOCS3(Mocs3) - CSB-YP014707MO CSB-EP014707MO CSB-BP014707MO CSB-MP014707MO from Cusabio
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Adenylyltransferase and sulfurtransferase MOCS3 (Mocs3) - MBS1057055 from MyBioSource
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Recombinant Mouse MOCS3 Protein - MOCS3-9950M from Creative Biomart
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