DOCK1

Gene Symbol DOCK1
Entrez Gene 1793
Alt Symbol DOCK180, ced5
Species Human
Gene Type protein-coding
Description dedicator of cytokinesis 1
Other Description 180 kDa protein downstream of CRK|DOwnstream of CrK|dedicator of cytokinesis protein 1
Swissprots A9Z1Z5 Q14185
Accessions EAW49194 Q14185 AI951513 AK091673 AL157538 AW298149 BC084559 BC144632 BC146857 AAI46858 BP205399 BU556771 BU626553 BX482033 BX648342 CD104773 CF455012 CX163251 D50857 BAA09454 DA350224 XM_011539421 XP_011537723 XM_011539422 XP_011537724 XM_011539423 XP_011537725 XM_011539424 XP_011537726 XM_011539425 XP_011537727 XM_011539426 XP_011537728 NM_001290223 NP_001277152 NM_001380 NP_001371
Function Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. {ECO:0000269|PubMed:8657152}.
Subcellular Location Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000305}.
Tissue Specificity Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
Top Pathways Focal adhesion, Bacterial invasion of epithelial cells, Regulation of actin cytoskeleton

DOCK180 (C4C12) Rabbit mAb - 4846 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C4C12
Western blot analysis of extracts from various cell types, using DOCK180 (C4C12) Rabbit mAb.

DOCK 180 (E-2) - sc-514080 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DOCK 180 (E-2): sc-514080. Western blot analysis of DOCK 180 expression in PC-12 (A), H4 (B), A-431 (C), HeLa (D), JAR (E) and MCF7 (F) whole cell lysates.

DOCK 180 (H-4) - sc-13163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DOCK 180 (H-4): sc-13163. Immunoperoxidase staining of formalin fixed, paraffin-embedded human tonsil tissue showing membrane and cytoplasmic staining of non-follicle cells and surface epithelial cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

DOCK 180 (C-19) - sc-6167 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DOCK 180 (C-19): sc-6167. Western blot analysis of DOCK 180 expression in 143B (A), A-431 (B), 3T3-L1 (C) and PC-12 (D) whole cell lysates.

DOCK 180 (H-70) - sc-5625 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DOCK 180 (H-70): sc-5625. Western blot analysis of DOCK 180 expression in HeLa (A) and JAR (B) whole cell lysates.

DOCK 180 (N-19) - sc-6043 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DOCK 180 (N-19): sc-6043. Western blot analysis of DOCK 180 expression in 3T3-L1 (A) and PC-12 (B) whole cell lysates.

Anti-DOCK1 antibody - ab97325 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-DOCK1 antibody (ab97325) at 1/1000 dilution + 293T whole cell lysate at 30 µg

Anti-DOCK1 antibody - ab76927 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DOCK1 antibody (ab76927) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgLane 5 : NIH3T3 whole cell lysate at 50 µg

Anti-DOCK1 antibody - ab92710 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DOCK1 antibody (ab92710) at 1/500 dilutionLane 1 : HeLa cell lysateLane 2 : HeLa cell lysate with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-DOCK1 antibody - ab1348 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
DOCK1 staining (4µg/ml) of A431 lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence

Anti-DOCK1 antibody - ab75278 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of DOCK1 by Western Blot of Immunprecipitate. anti-DOCK1 at 1µg/ml staining DOCK1 in HeLa whole cell lysate immunoprecipitated using ab75278 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 3 seconds.

Anti-DOCK180 / DOCK1 Antibody (aa1715-1765) - LS-C288096 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DOCK180 / DOCK1 Antibody (aa1815-1865) - LS-C288098 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DOCK180 / DOCK1 Antibody (aa1200-1435, Biotin) - LS-C301019 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DOCK180 / DOCK1 Antibody (Lys1692) - LS-C177821 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of DOCK 180 (K1692) pAb in extracts from HUVEC cells.

Anti-DOCK180 / DOCK1 Antibody (aa1200-1435, FITC) - LS-C303547 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DOCK180 / DOCK1 Antibody (aa1852-1865) - LS-C54728 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (4 ug/ml) of A431 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 12 hour. Detected by Western blot of chemiluminescence.

Anti-DOCK180 / DOCK1 Antibody (aa1200-1435) - LS-C293651 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant DOCK180 / DOCK1.

Anti-DOCK180 / DOCK1 Antibody (aa1661-1710) - LS-C119897 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa cells, using DOCK1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-DOCK180 / DOCK1 Antibody (clone 3D10) - LS-C197069 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D10
DOCK1 monoclonal antibody (M02), clone 3D10. Western Blot analysis of DOCK1 expression in human colon.

Anti-DOCK180 / DOCK1 Antibody (aa1802-1865) - LS-C185349 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Lung CA using DOCK 180 antibody at 1:100 dilution.

DOCK1 Antibody - NBP1-30945 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: DOCK1 Antibody [NBP1-30945] - Sample(30 ug of whole cell lysate)A:293T7. 5% SDS PAGE, antibody diluted at 1:1000.

DOCK1 Antibody - AF7070 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HUVEC human umbilical vein endothelial cells, HepG2 human hepatocellular carcinoma cell line, C6 rat glioma cell line, and PC‑12 rat adrenal pheochromocytoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human DOCK1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7070) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for DOCK1 at approximately 180 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

DOCK1 Antibody - NBP2-38586 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DOCK1 Antibody - NB100-828 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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