DOCK1

Gene Symbol DOCK1
Entrez Gene 1793
Alt Symbol DOCK180, ced5
Species Human
Gene Type protein-coding
Description dedicator of cytokinesis 1
Other Description 180 kDa protein downstream of CRK|DOwnstream of CrK|dedicator of cytokinesis protein 1
Swissprots A9Z1Z5 Q14185
Accessions EAW49194 Q14185 AI951513 AK091673 AL157538 AW298149 BC084559 BC144632 BC146857 AAI46858 BP205399 BU556771 BU626553 BX482033 BX648342 CD104773 CF455012 CX163251 D50857 BAA09454 DA350224 XM_011539421 XP_011537723 XM_011539422 XP_011537724 XM_011539423 XP_011537725 XM_011539424 XP_011537726 XM_011539425 XP_011537727 XM_011539426 XP_011537728 NM_001290223 NP_001277152 NM_001380 NP_001371
Function Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. {ECO:0000269|PubMed:8657152}.
Subcellular Location Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000305}.
Tissue Specificity Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
Top Pathways Focal adhesion, Bacterial invasion of epithelial cells, Regulation of actin cytoskeleton

Human DOCK1 full length protein - ab114754 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE Stained with Coomassie Blue showing ab114754 at approximately 42.79kDa.

Human DOCK1 peptide - ab22812 from Abcam

Category Peptide
Species Human

Human DOCK1 protein fragment - ab114755 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE Stained with Coomassie Blue showing ab114755 at approximately 37.29kDa.

DOCK180 / DOCK1 Antibody Blocking Peptide - LS-E25247 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human DOCK1 Protein - H00001793-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human DOCK1 Protein - H00001793-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

DOCK1 blocking peptide - GTX89965-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human, Mouse, Dog, Pig, Rat, Bovine

Human DOCK1 Protein - abx066282 from Abbexa

Category Protein
Source E.coli
Species Human

DOCK1 Peptide - AC21-0074-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

DOCK1 / DOCK180 - H00001793-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

DOCK1 / DOCK180 - H00001793-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

DOCK1 / DOCK180 - H00001793-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

DOCK1 / DOCK180 - H00001793-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Dedicator Of Cytokinesis 1 (DOCK1), Human - 20-9145 from ARP American Research Products

Category Protein
Prices $479.00
Sizes 50 µg
Source E.coli
Species Human

DOCK1 Peptide - 45-489P from ProSci

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human

DOCK1 fusion protein - ag18069 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

DOCK1 fusion protein - ag16342 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human DOCK1 - DOCK1-26153TH from Creative Biomart

Category Protein
Source Wheat germ

Recombinant Human DOCK1 - DOCK1-26951TH from Creative Biomart

Category Protein
Source Wheat germ

Recombinant Dedicator Of Cytokinesis 1 (DOCK1) - RPG175Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

DOCK 180 (K1692) Peptide - BS3846P from Bioworld Technology

Category Peptide
Prices $158.00
Sizes 100 µl

Recombinant Dedicator Of Cytokinesis 1 (DOCK1) - RPG175Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

Recombinant Human Dedicator of cytokinesis protein 1(DOCK1) ,partial - CSB-YP619864HU CSB-EP619864HU CSB-BP619864HU CSB-MP619864HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

DOCK 180 (1700-1769) - sc-4481 WB from Santa Cruz Biotechnology

Category Protein
Prices $88.00
Sizes 10 µg/0.1 ml
Species Human

Dedicator Of Cytokinesis 1 (DOCK1) - RPU141150 from Biomatik

Category Protein
Prices $225.50, $451.00, $676.50
Sizes 10 µg, 50 µg, 100 µg
Source E.coli
Species Human
Search more