DOCK1

Gene Symbol DOCK1
Entrez Gene 1793
Alt Symbol DOCK180, ced5
Species Human
Gene Type protein-coding
Description dedicator of cytokinesis 1
Other Description 180 kDa protein downstream of CRK|DOwnstream of CrK|dedicator of cytokinesis protein 1
Swissprots A9Z1Z5 Q14185
Accessions EAW49194 Q14185 AI951513 AK091673 AL157538 AW298149 BC084559 BC144632 BC146857 AAI46858 BP205399 BU556771 BU626553 BX482033 BX648342 CD104773 CF455012 CX163251 D50857 BAA09454 DA350224 XM_011539421 XP_011537723 XM_011539422 XP_011537724 XM_011539423 XP_011537725 XM_011539424 XP_011537726 XM_011539425 XP_011537727 XM_011539426 XP_011537728 NM_001290223 NP_001277152 NM_001380 NP_001371
Function Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. {ECO:0000269|PubMed:8657152}.
Subcellular Location Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000305}.
Tissue Specificity Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
Top Pathways Focal adhesion, Bacterial invasion of epithelial cells, Regulation of actin cytoskeleton

Panoply™ Human DOCK1 Knockdown Stable Cell Line - CSC-DC004471 from Creative biogene

Category Cell Line
Species Human
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