HES1

Gene Symbol HES1
Entrez Gene 3280
Alt Symbol HES-1, HHL, HRY, bHLHb39
Species Human
Gene Type protein-coding
Description hes family bHLH transcription factor 1
Other Description class B basic helix-loop-helix protein 39|hairy homolog|hairy-like protein|transcription factor HES-1
Swissprots Q14469 Q6FHB2
Accessions AAA65220 EAW78058 Q14469 AF264785 AAF73060 AI370424 AK000415 BAA91149 AK300482 BAG62198 BC005178 AAH05178 BC039152 AAH39152 BC156516 AAI56517 BC172546 AAI72546 CR541843 CAG46641 DQ891328 ABM82254 DQ893354 ABM84280 DQ896673 ABM87672 DW424342 NM_005524 NP_005515
Function Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}.
Subcellular Location Nucleus.
Top Pathways Notch signaling pathway, Maturity onset diabetes of the young, Fanconi anemia pathway

Human HES1 ORF Clone(NM_005524.3) - CDCL165954 from Creative Biomart

Species Human
Accession NM_005524.3
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