HES1

Gene Symbol HES1
Entrez Gene 3280
Alt Symbol HES-1, HHL, HRY, bHLHb39
Species Human
Gene Type protein-coding
Description hes family bHLH transcription factor 1
Other Description class B basic helix-loop-helix protein 39|hairy homolog|hairy-like protein|transcription factor HES-1
Swissprots Q14469 Q6FHB2
Accessions AAA65220 EAW78058 Q14469 AF264785 AAF73060 AI370424 AK000415 BAA91149 AK300482 BAG62198 BC005178 AAH05178 BC039152 AAH39152 BC156516 AAI56517 BC172546 AAI72546 CR541843 CAG46641 DQ891328 ABM82254 DQ893354 ABM84280 DQ896673 ABM87672 DW424342 NM_005524 NP_005515
Function Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}.
Subcellular Location Nucleus.
Top Pathways Notch signaling pathway, Maturity onset diabetes of the young, Fanconi anemia pathway

HES1 (D6P2U) Rabbit mAb - 11988 from Cell Signaling Technology

Prices $250.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6P2U
Western blot analysis of extracts from various cell lines using HES1 (D6P2U) Rabbit mAb.

HES1 (A-12) - sc-166378 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HES1 (A-12): sc-166378. Western blot analysis of HES1 expression in non-transfected: sc-117752 (A) and human HES1 transfected: sc-113854 (B) 293T whole cell lysates.

HES1 (E-5) - sc-166410 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HES1 (E-5): sc-166410. Western blot analysis of HES1 expression in non-transfected: sc-117752 (A) and human HES1 transfected: sc-113854 (B) 293T whole cell lysates.

HES1 (F-10) - sc-165996 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HES1 (F-10): sc-165996. Western blot analysis of HES1 expression in non-transfected: sc-117752 (A) and human HES1 transfected: sc-113854 (B) 293T whole cell lysates.

HES1 (H-140) - sc-25392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HES1 (H-140): sc-25392. Western blot analysis of HES1 expression in non-transfected: sc-117752 (A) and human HES1 transfected: sc-113854 (B) 293T whole cell lysates.

HES1 (H-20) - sc-13844 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HES1 (H-20): sc-13844. Western blot analysis of HES1 expression in non-transfected: sc-117752 (A) and human HES1 transfected: sc-113854 (B) 293T whole cell lysates.

HES1 (N-17) - sc-13842 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HES1 (N-17): sc-13842. Western blot analysis of HES1 expression in non-transfected: sc-117752 (A) and human HES1 transfected: sc-113854 (B) 293T whole cell lysates.

Anti-Hes1 antibody - ab71559 from Abcam

Prices $400.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab71559 staining Hes1 in Mouse skin tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with acetone/methanol (1:1), permeabilized with PBS + triton X100 (0.025%) and blocked with 10% serum for 1 hour at room temperature. Samples were incubated with primary antibody (1/100 in PBS) for 8 hours at 4°C. An Alexa Fluor®555-conjugated goat anti-rabbit IgG polyclonal (1/1000) was used as the secondary antibody. See Abreview

Anti-Hes1 antibody - ab55265 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Hes1 antibody [2D2] - ab119776 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D2
All lanes : Anti-Hes1 antibody [2D2] (ab119776) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNA Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Hes1 cDNA Lysates/proteins at 5 µg per lane.

Anti-Hes1 antibody [4H1] - ab87395 from Abcam

Prices $379.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4H1
ab87395 at 1/50 dilution staining Hes 1 in paraffin-embedded Human endometrium.

Anti-Hes1 antibody [7H11] - ab70576 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7H11
All lanes : Anti-Hes1 antibody [7H11] (ab70576) at 1/500 dilutionLane 1 : BeWo cell lysateLane 2 : HT-29 cell lysate

Anti-Hes1 antibody [EPR4226] - ab108937 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4226
Anti-Hes1 antibody [EPR4226] (ab108937) at 1/1000 dilution (purified) + SH-SY5Y cell lysate at 10 µgSecondaryHRP goat anti-rabbit (H+L) at 1/1000 dilution

Anti-Hes1 antibody [EPR4226] (Alexa Fluor® 488) - ab196328 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4226
ab196328 staining Hes1 in SKNSH cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab196328 at 1/100 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 2 µg/ml (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-Hes1 antibody [EPR4226] (Alexa Fluor® 647) - ab196577 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4226
ab196577 staining Hes1 in SK-N-SH cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab196577 at 1/200 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at 1/250 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in SK-N-SH cells fixed with 100% methanol (5min).

Anti-Hes1 antibody - Aminoterminal end - ab70933 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Hes1 antibody - Aminoterminal end (ab70933) at 1/60 dilution + HL60 cell line lysates at 35 µg

Anti-Hes1 antibody - C-terminal - ab157181 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Hes1 antibody - C-terminal (ab157181) at 1/1000 dilution + Mouse brain total cell extract

Anti-HES1 / HES-1 Antibody (clone 1F11) - LS-C173571 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F11
IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-HES1 mouse monoclonal antibody.

Anti-HES1 / HES-1 Antibody (clone 7B9) - LS-C173600 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7B9
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-HES1 mouse monoclonal antibody.

Anti-HES1 / HES-1 Antibody (clone 4D9) - LS-C197458 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D9
HES1 monoclonal antibody (M01), clone 4D9 Western Blot analysis of HES1 expression in THP-1.

Anti-HES1 / HES-1 Antibody (aa9-38) - LS-C99985 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Confocal immunofluorescent of HES1 Antibody (N-term T24) with HeLa cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).

Anti-HES1 / HES-1 Antibody (clone 2H4) - LS-C337591 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HES1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HES1.

Anti-HES1 / HES-1 Antibody (clone NM1) - LS-C179395 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone NM1

Anti-HES1 / HES-1 Antibody (clone 1H8) - LS-C173543 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H8
Anti-HES1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY HES1.

Anti-HES1 / HES-1 Antibody (aa142-155) - LS-C313297 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of HES1 / HES-1 antibody. WB: Rat Kidney Tissue Lysate.
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