PDX1

Gene Symbol	PDX1
Entrez Gene	3651
Alt Symbol	GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1
Species	Human
Gene Type	protein-coding
Description	pancreatic and duodenal homeobox 1
Other Description	IPF-1|IUF-1|glucose-sensitive factor|insulin promoter factor 1, homeodomain transcription factor|insulin upstream factor 1|islet/duodenum homeobox-1|pancreas/duodenum homeobox protein 1|pancreatic-duodenal homeobox factor 1|somatostatin transcription factor 1|somatostatin-transactivating factor 1
Swissprots	Q5VYW2 O60594 P52945
Accessions	AAB47101 AAB88463 EAX08420 P52945 AF049893 AAC05157 BC111592 AAI11593 CA771381 CA848737 U30329 AAA74012 U35632 AAA88820 X99894 CAA68169 XR_941578 XR_941579 XR_941580 NM_000209 NP_000200
Function	Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
Subcellular Location	Nucleus. Cytoplasm, cytosol {ECO:0000250}.
Tissue Specificity	Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).
Top Pathways	Type II diabetes mellitus, Maturity onset diabetes of the young

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Mouse PDX1 ELISA Kit (Sandwich ELISA) - LS-F9697 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

pancreatic and duodenal homeobox 1, ELISA Kit - MBS9334734 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Insulin Promoter Factor 1 (IPF) - SEH792Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.054ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse PDX1 ELISA Kit (Custom ELISA) - LS-F20293 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human PDX1 ELISA Kit (Sandwich ELISA) - LS-F20294 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 15.6 Range 0.156-10 ng/ml

Rat PDX1 ELISA Kit (Sandwich ELISA) - LS-F20295 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Custom Human PDX-1 ELISA - ELH-PDX from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human PDX-1 ELISA - RAB1633 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

PDX1 ELISA Kit (Human) : 96 Wells (OKEH01900) - OKEH01900 from Aviva Systems Biology Category ELISA Kit Prices $450.00 Sizes 96 wells Sensitivity < 1.7 pg/mL Range 15.6 - 1000 pg/mL

Custom Human PDX-1 ELISA - ELH-PDX-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Pancreas/duodenum homeobox protein 1 ELISA Kit - EK4887 from Signalway Antibody Category ELISA Kit Prices $659.00 Sizes 1x96t Range 0.156-10 ng/ml

Pancreas/duodenum homeobox protein 1, ELISA Kit - MBS289476 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 15.6-1000 pg/mL

Pancreas/duodenum homeobox protein 1, ELISA Kit - MBS9428713 from MyBioSource Category ELISA Kit Prices $605.00 Sizes 96 tests Sensitivity Less than 1.7pg/mL Range 15.6-1000 pg/mL

Human PDX1 ELISA Kit (Sandwich ELISA) - LS-F35579 from LifeSpan Bioscience Category ELISA Kit Sensitivity 9.375 Range 0.156-10 ng/ml

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