PDX1

Gene Symbol	PDX1
Entrez Gene	3651
Alt Symbol	GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1
Species	Human
Gene Type	protein-coding
Description	pancreatic and duodenal homeobox 1
Other Description	IPF-1|IUF-1|glucose-sensitive factor|insulin promoter factor 1, homeodomain transcription factor|insulin upstream factor 1|islet/duodenum homeobox-1|pancreas/duodenum homeobox protein 1|pancreatic-duodenal homeobox factor 1|somatostatin transcription factor 1|somatostatin-transactivating factor 1
Swissprots	Q5VYW2 O60594 P52945
Accessions	AAB47101 AAB88463 EAX08420 P52945 AF049893 AAC05157 BC111592 AAI11593 CA771381 CA848737 U30329 AAA74012 U35632 AAA88820 X99894 CAA68169 XR_941578 XR_941579 XR_941580 NM_000209 NP_000200
Function	Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
Subcellular Location	Nucleus. Cytoplasm, cytosol {ECO:0000250}.
Tissue Specificity	Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).
Top Pathways	Type II diabetes mellitus, Maturity onset diabetes of the young

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human PDX1 full length protein - ab114175 from Abcam Category Protein Source Wheat germ Species Human

Phospho-PDX1T11-Antibody-Blocking-peptide - BP3669a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-IPFS66-Antibody-Blocking-peptide - BP3618a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-IPFT11-Antibody-Blocking-peptide - BP3617a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

IPF-Antibody-C-term-Blocking-Peptide - BP7740b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDX1-Antibody-N-term-Blocking-peptide - BP7740a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDX1 blocking peptide - GTX89374-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

PDX-1 protein - orb197660 from Biorbyt Category Protein Prices $255.00, $391.00, $519.00 Sizes 10 μg, 50 μg, 100 μg Species Human

Insulin promoter factor 1 - H00003651-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Recombinant Human PDX-1 - 230-00564-10 from RayBiotech Category Protein Prices $110.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human PDX-1 - 230-00564-50 from RayBiotech Category Protein Prices $224.00 Sizes 50 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human PDX-1 - 230-00564-100 from RayBiotech Category Protein Prices $336.00 Sizes 100 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human PDX1 - PDX1-29672TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Pancreatic And Duodenal Homeobox 1 - PDX1-176H from Creative Biomart Category Protein Source Escherichia Coli .

Recombinant Insulin Promoter Factor 1 (IPF) - RPH792Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Insulin Promoter Factor 1 (IPF) - RPH792Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human Pancreas/duodenum homeobox protein 1(PDX1) - CSB-YP017746HU CSB-EP017746HU CSB-BP017746HU CSB-MP017746HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human PDX-1/IPF1 Protein - H00003651-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Insulin promoter factor 1 - TP322354 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Insulin promoter factor 1 (N-term HIS tag) - TP760660 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Pancreas/duodenum homeobox protein 1 (PDX1), Recombinant Protein - MBS956388 from MyBioSource Category Protein Prices $1,035.00, $1,035.00, $1,265.00, $1,265.00, $1,610.00, $1,610.00, $2,075.00, $2,075.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

IPF-Antibody-S66-Blocking-Peptide - BP7740e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IPF-Antibody-T11-Blocking-Peptide - BP7740d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDX1-Blocking-Peptide-N-term - BP20965b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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