| Gene Symbol |
PDX1
|
| Entrez Gene |
3651
|
| Alt Symbol |
GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pancreatic and duodenal homeobox 1
|
| Other Description |
IPF-1|IUF-1|glucose-sensitive factor|insulin promoter factor 1, homeodomain transcription factor|insulin upstream factor 1|islet/duodenum homeobox-1|pancreas/duodenum homeobox protein 1|pancreatic-duodenal homeobox factor 1|somatostatin transcription factor 1|somatostatin-transactivating factor 1
|
| Swissprots |
Q5VYW2 O60594 P52945
|
| Accessions |
AAB47101 AAB88463 EAX08420 P52945 AF049893 AAC05157 BC111592 AAI11593 CA771381 CA848737 U30329 AAA74012 U35632 AAA88820 X99894 CAA68169 XR_941578 XR_941579 XR_941580 NM_000209 NP_000200
|
| Function |
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
|
| Subcellular Location |
Nucleus. Cytoplasm, cytosol {ECO:0000250}.
|
| Tissue Specificity |
Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).
|
| Top Pathways |
Type II diabetes mellitus, Maturity onset diabetes of the young
|
![Western Blot: PDX1 Overexpression Lysate (Adult Normal) [NBL1-14266] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDX1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7326_PDX1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14266-img0002.jpg)