Gene Symbol | MSH3 |
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Entrez Gene | 4437 |
Alt Symbol | DUP, MRP1 |
Species | Human |
Gene Type | protein-coding |
Description | mutS homolog 3 |
Other Description | DNA mismatch repair protein Msh3|divergent upstream protein|hMSH3|mismatch repair protein 1 |
Swissprots | Q6PJT5 Q86UQ6 A1L482 A6NMM6 A1L480 Q92867 P20585 |
Accessions | AAP13535 BAD27111 EAW95861 EAW95862 P20585 AA601983 AI817671 AK289856 BAF82545 BC004177 BC011817 AAH11817 BC017273 BC098436 BC130434 AAI30435 BC130436 AAI30437 BF593920 J04810 AAB47281 U61981 AAB06045 NM_002439 NP_002430 |
Function | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. |
Top Pathways | Mismatch repair, Colorectal cancer |
MSH3 (B-4) - sc-271080 from Santa Cruz Biotechnology
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MSH3 (C-8) - sc-271079 from Santa Cruz Biotechnology
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MSH3 (H-300) - sc-11441 from Santa Cruz Biotechnology
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MSH3 (S-16) - sc-5686 from Santa Cruz Biotechnology
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Anti-MSH3 antibody - ab93663 from Abcam
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Anti-MSH3 antibody - ab69619 from Abcam
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Anti-MSH3 antibody - ab157245 from Abcam
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Anti-MSH3 antibody [EPR4334(2)] - ab111107 from Abcam
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Anti-MSH3 antibody - C-terminal - ab154521 from Abcam
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Anti-MSH3 antibody - N-terminal - ab154486 from Abcam
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MSH3 Antibody - NBP1-84965 from Novus Biologicals
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MSH3 Antibody - NBP2-19417 from Novus Biologicals
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MSH3 Antibody - NBP1-84966 from Novus Biologicals
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MSH3 Antibody - NBP2-19418 from Novus Biologicals
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MSH3 Polyclonal Antibody - bs-4919R from Bioss
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MSH3 Polyclonal Antibody - bs-8542R from Bioss
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Anti-MSH3 antibody produced in rabbit - HPA036081 from Sigma-Aldrich
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Anti-MSH3, N-Terminal antibody produced in rabbit - SAB4501924 from Sigma-Aldrich
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Anti-MSH3 (center) antibody produced in rabbit - SAB1300711 from Sigma-Aldrich
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Anti-MSH3 antibody produced in rabbit - HPA036080 from Sigma-Aldrich
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MSH3 antibody [C2C3], C-term - GTX113781 from GeneTex
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MSH3 antibody [EPR4334(2)] - GTX63098 from GeneTex
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MSH3 antibody [EPR4334] - GTX62980 from GeneTex
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MSH3 antibody [N1N2], N-term - GTX103228 from GeneTex
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MSH3 Antibody (OAAF03052) - OAAF03052 from Aviva Systems Biology
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