NAIP

Gene Symbol NAIP
Entrez Gene 4671
Alt Symbol BIRC1, NLRB1, psiNAIP
Species Human
Gene Type protein-coding
Description NLR family, apoptosis inhibitory protein
Other Description baculoviral IAP repeat-containing protein 1|neuronal apoptosis inhibitory protein|nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1|psi neuronal apoptosis inhibitory protein
Swissprots Q99796 E9PHD1 Q13730 O75857 B9EG72 Q13075 Q8TDZ4 Q59GI6
Accessions AAC52047 AAC62261 EAW50510 Q13075 AB048534 BAB87181 AB209123 BAD92360 AK124511 AK295115 BAG58144 AK309627 AK311046 BC136273 AAI36274 BC143761 AAI43762 DQ786305 U19251 AAC52045 XM_005248523 XP_005248580 XM_005248524 XP_005248581 XM_005276800 XP_005276857 XM_005276801 XP_005276858 XM_005276802 XP_005276859 XM_006714626 XP_006714689 XM_006714629 XP_006714692 XM_006714630 XP_006714693 XM_006725453 XP_006725516 XM_006725456 XP_006725519 XM_006725457 XP_006725520 XM_006725458 XP_006725521 XM_006725459 XP_006725522 XM_006726219 XP_006726282 XM_006726222 XP_006726285 XM_011543409 XP_011541711 XM_011543410 XP_011541712 XM_011543411 XP_011541713 XM_011543412 XP_011541714 XM_011543413 XP_011541715 XM_011546973 XP_011545275 XM_011546974 XP_011545276 XM_011546975 XP_011545277 XM_011546976 XP_011545278 XM_011546977 XP_011545279 XM_011546978 XP_011545280 XM_011546979 XP_011545281 XM_011547345 XP_011545647 XM_011547346 XP_011545648 XM_011547347 XP_011545649 XM_011547348 XP_011545650 XM_011547349 XP_011545651 NM_004536 NP_004527 NM_022892 NP_075043
Function Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.
Tissue Specificity Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.
Top Pathways NOD-like receptor signaling pathway, Legionellosis

NAIP (G-20) - sc-11060 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NAIP (P-16) - sc-11059 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NAIP1 (S-20) - sc-11067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NAIP antibody - ab25968 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NAIP antibody - ab198819 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling NAIP with ab198819 at a 1/30 dilution.

Anti-NAIP antibody - ab98020 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NAIP antibody (ab98020) at 1 µg/ml + Liver (Human) Tissue Lysate - adult normal tissue (ab29889) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-NAIP antibody - ab2549 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NAIP antibody (ab2549) at 1/1000 dilutionLane 1 : Lysate prepared from transfected PC3 cells.Lane 2 : Lysate prepared from non-transfected PC3 cells.Lane 3 : Lysate prepared from transfected HeLa cells.Lane 4 : Lysate prepared from non-transfected HeLa cells.Lane 5 : Lysate prepared from non-transfected NTera2D1 cells.Secondarysecondary antibody at 1/100000 dilutionObserved band size : 160 kDa (why is the actual band size different from the predicted?)Additional bands at : 105 kDa (possible isoform),115 kDa,130 kDa (possible isoform). We are unsure as to the identity of these extra bands.Image from Dr MT Romanish et al, PLoS One. 2009 Jun 2;4(6):e5761, Fig 5.

Anti-NAIP antibody [EPR6169] - ab129079 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6169
All lanes : Anti-NAIP antibody [EPR6169] (ab129079) at 1/1000 dilutionLane 1 : Human tonsil cell lysateLane 2 : Human placenta cell lysateLane 3 : Human fetal kidney cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-rabbit HRP

Anti-BIRC1 / NAIP Antibody - LS-C48264 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BIRC1 / NAIP Antibody (aa5-18) - LS-C112946 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-BIRC1 / NAIP Antibody (C-Terminus) - LS-C121410 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-BIRC1 / NAIP Antibody (Internal, clone EPR6169) - LS-C152585 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6169
Western blot analysis on (A) human tonsil, (B) human placenta, and (C) fetal kidney lysates using anti-NAIP antibody.

Anti-BIRC1 / NAIP Antibody (aa500-759) - LS-C295587 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant BIRC1 / NAIP.

Anti-BIRC1 / NAIP Antibody (C-Terminus) IHC-plus™ - LS-B455 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NAIP antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B455 concentration 5 ug/ml.

NAIP Antibody (541609) [Unconjugated] - MAB829 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 541609
Western blot shows lysates of HEK293 human embryonic kidney cell line either mock transfected or transfected with human NAIP and human brain (cerebellum) tissue. PVDF Membrane was probed with 1 µg/mL of Human NAIP Monoclonal Antibody (Catalog # MAB829) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for NAIP at approximately 160 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.

NAIP Antibody [Unconjugated] - AF829 from Novus Biologicals

Prices $99.00, $289.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot shows lysates of Sf 21 insect cells before (lane 1) and 48 hours post infection with human NAIP (lane 2). PVDF membrane was probed with 1 µg/mL Rabbit Anti-Human NAIP Antigen Affinity-purified Polyclonal Antibody (Catalog # AF829) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008). A specific band for truncated NAIP was detected at approximately 130 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 4.

NAIP Antibody - NBP1-77196 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: NAIP Antibody [NBP1-77196] - Analysis of NAIP in human tonsil tissue lysate with NAIP antibody at 1 ug/mL.

NAIP Antibody - NBP1-88596 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: NAIP Antibody [NBP1-88596] - Staining of human placenta shows moderate cytoplasmic positivity in trophoblastic cells.

NAIP Antibody - 32200002 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ELISA: NAIP Antibody [32200002]

NAIP Antibody - NBP1-52155 from Novus Biologicals

Prices $199.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

NAIP Antibody - H00004671-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

NAIP Polyclonal Antibody - bs-5804R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NAIP antibody produced in rabbit - PRS3315 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunocytochemistry</B><BR/>Anti-NAIP: <B>Cat. No. PRS3315</B> Immunocytochemistry of NAIP in A549 cells with NAIP antibody at 10 μg/mL.

Anti-NAIP antibody produced in rabbit - HPA042438 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NAIP: <B>Cat. No. HPA042438</B>: Immunohistochemical staining of human placenta shows moderate cytoplasmic positivity in trophoblastic cells.

Anti-NAIP/BIRC1 antibody produced in rabbit - SAB2900353 from Sigma-Aldrich

Prices $464.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NAIP/BIRC1: <B>Cat. No.SAB2900353</B>: Placenta: Formalin-Fixed Paraffin-Embedded (FFPE).
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