NAIP

Gene Symbol	NAIP
Entrez Gene	4671
Alt Symbol	BIRC1, NLRB1, psiNAIP
Species	Human
Gene Type	protein-coding
Description	NLR family, apoptosis inhibitory protein
Other Description	baculoviral IAP repeat-containing protein 1|neuronal apoptosis inhibitory protein|nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1|psi neuronal apoptosis inhibitory protein
Swissprots	Q99796 E9PHD1 Q13730 O75857 B9EG72 Q13075 Q8TDZ4 Q59GI6
Accessions	AAC52047 AAC62261 EAW50510 Q13075 AB048534 BAB87181 AB209123 BAD92360 AK124511 AK295115 BAG58144 AK309627 AK311046 BC136273 AAI36274 BC143761 AAI43762 DQ786305 U19251 AAC52045 XM_005248523 XP_005248580 XM_005248524 XP_005248581 XM_005276800 XP_005276857 XM_005276801 XP_005276858 XM_005276802 XP_005276859 XM_006714626 XP_006714689 XM_006714629 XP_006714692 XM_006714630 XP_006714693 XM_006725453 XP_006725516 XM_006725456 XP_006725519 XM_006725457 XP_006725520 XM_006725458 XP_006725521 XM_006725459 XP_006725522 XM_006726219 XP_006726282 XM_006726222 XP_006726285 XM_011543409 XP_011541711 XM_011543410 XP_011541712 XM_011543411 XP_011541713 XM_011543412 XP_011541714 XM_011543413 XP_011541715 XM_011546973 XP_011545275 XM_011546974 XP_011545276 XM_011546975 XP_011545277 XM_011546976 XP_011545278 XM_011546977 XP_011545279 XM_011546978 XP_011545280 XM_011546979 XP_011545281 XM_011547345 XP_011545647 XM_011547346 XP_011545648 XM_011547347 XP_011545649 XM_011547348 XP_011545650 XM_011547349 XP_011545651 NM_004536 NP_004527 NM_022892 NP_075043
Function	Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.
Tissue Specificity	Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.
Top Pathways	NOD-like receptor signaling pathway, Legionellosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NAIP CRISPR/Cas9 KO Plasmid (h) - sc-418189 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NAIP HDR Plasmid (h) - sc-418189-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NAIP Double Nickase Plasmid (h) - sc-418189-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NAIP Double Nickase Plasmid (h2) - sc-418189-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NAIP CRISPR Activation Plasmid (h) - sc-418189-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NAIP CRISPR Activation Plasmid (h2) - sc-418189-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

NAIP Lentiviral Activation Particles (h) - sc-418189-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NAIP Lentiviral Activation Particles (h2) - sc-418189-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

NAIP1 siRNA (h) - sc-42038 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NAIP1 shRNA Plasmid (h) - sc-42038-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NAIP1 shRNA (h) Lentiviral Particles - sc-42038-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NAIP RNAi - H00004671-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU114891 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU104971 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14936 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14936 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12698 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr12698

NAIP siRNA (Human) - CRH3089 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human NAIP(NM_022892.1) - SHH215183 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human NAIP(NM_004536.2) - SHH215201 from Creative biogene Category siRNA Species Reactivities Human

Human NAIP siRNA - orb263591 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NAIP shRNA Plasmid (Human) - CHH3089 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

NAIP miRNA 3'UTR clone - MiUTR1H-06626 from Creative biogene Species Reactivities Human

NAIP miRNA 3'UTR clone - MiUTR1H-06627 from Creative biogene Species Reactivities Human

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