| Gene Symbol |
Fbxo32
|
| Entrez Gene |
67731
|
| Alt Symbol |
4833442G10Rik, AI430017, ATROGIN1, Gm20361, MAFbx
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 32
|
| Other Description |
F-box only protein 32|atrogin 1|muscle atrophy F-box protein
|
| Swissprots |
Q9CPU7
|
| Accessions |
EDL29301 Q9CPU7 AF441120 AAL49563 AK014612 BAB29463 AK014793 BAB29555 AK033632 AK033658 AK190642 AK202405 AK216124 BB838158 BC027211 AAH27211 BU921446 NM_026346 NP_080622
|
| Function |
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between Cytoplasm and the nucleus. {ECO:0000250}.
|
| Tissue Specificity |
Specifically expressed in cardiac and skeletal muscle.
|