Gene Symbol | Fbxo32 |
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Entrez Gene | 67731 |
Alt Symbol | 4833442G10Rik, AI430017, ATROGIN1, Gm20361, MAFbx |
Species | Mouse |
Gene Type | protein-coding |
Description | F-box protein 32 |
Other Description | F-box only protein 32|atrogin 1|muscle atrophy F-box protein |
Swissprots | Q9CPU7 |
Accessions | EDL29301 Q9CPU7 AF441120 AAL49563 AK014612 BAB29463 AK014793 BAB29555 AK033632 AK033658 AK190642 AK202405 AK216124 BB838158 BC027211 AAH27211 BU921446 NM_026346 NP_080622 |
Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between Cytoplasm and the nucleus. {ECO:0000250}. |
Tissue Specificity | Specifically expressed in cardiac and skeletal muscle. |
MAFbx CRISPR/Cas9 KO Plasmid (m) - sc-426715 from Santa Cruz Biotechnology
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MAFbx HDR Plasmid (m) - sc-426715-HDR from Santa Cruz Biotechnology
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MAFbx Double Nickase Plasmid (m) - sc-426715-NIC from Santa Cruz Biotechnology
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MAFbx Double Nickase Plasmid (m2) - sc-426715-NIC-2 from Santa Cruz Biotechnology
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MAFbx CRISPR Activation Plasmid (m) - sc-426715-ACT from Santa Cruz Biotechnology
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MAFbx CRISPR Activation Plasmid (m2) - sc-426715-ACT-2 from Santa Cruz Biotechnology
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MAFbx Lentiviral Activation Particles (m) - sc-426715-LAC from Santa Cruz Biotechnology
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MAFbx Lentiviral Activation Particles (m2) - sc-426715-LAC-2 from Santa Cruz Biotechnology
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MAFbx siRNA (m) - sc-44807 from Santa Cruz Biotechnology
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MAFbx shRNA Plasmid (m) - sc-44807-SH from Santa Cruz Biotechnology
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MAFbx shRNA (m) Lentiviral Particles - sc-44807-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU043031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31245 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31245 from Sigma-Aldrich
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FBXO32 siRNA (Mouse) - CRM7317 from Cohesion Biosciences
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FBXO32 - MBS829395 from MyBioSource
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shRNA set against Mouse FBXO32 (NM_026346.3) - SHH293221 from Creative biogene
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Mouse FBXO32 siRNA - orb286793 from Biorbyt
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FBXO32 shRNA Plasmid (Mouse) - CHM7317 from Cohesion Biosciences
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