CTNNA1

Gene Symbol CTNNA1
Entrez Gene 1495
Alt Symbol CAP102
Species Human
Gene Type protein-coding
Description catenin (cadherin-associated protein), alpha 1, 102kDa
Other Description alpha E-catenin|alpha-E-catenin|alpha-catenin|alphaE-catenin|cadherin-associated protein,102kDa|catenin alpha-1|renal carcinoma antigen NY-REN-13
Swissprots Q8N1C0 Q12795 P35221
Accessions AAC99459 AAW56940 EAW62122 EAW62123 EAW62124 P35221 AI078507 AK055751 AK094151 BAG52830 AK296708 BAG59301 AK300439 BAG62162 AK304267 BAG65130 AU141929 BC000385 AAH00385 BC031262 AAH31262 BU624488 D13866 BAA02979 D14705 BAA03530 DA349847 DC369291 DQ891250 ABM82176 DQ894435 ABM85361 HQ589335 AEF32483 L22080 AAA35502 L23805 AAA86430 U03100 AAA18949 XM_005271899 XP_005271956 XM_006714536 XP_006714599 XM_011543172 XP_011541474 NM_001290307 NP_001277236 NM_001290309 NP_001277238 NM_001290310 NP_001277239 NM_001290312 NP_001277241 NM_001903 NP_001894
Function Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Subcellular Location Isoform 1: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.
Tissue Specificity Expressed ubiquitously in normal tissues.
Top Pathways Adherens junction, Tight junction, Leukocyte transendothelial migration, Endometrial cancer, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

α-E-Catenin Antibody - 3236 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using α-E-Catenin Antibody.

α-E-Catenin (23B2) Rabbit mAb - 3240 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 23B2
Western blot analysis of extracts from HUVEC, NIH/3T3, MCF-7, ZR-75 and A431 cells using α-E-Catenin (23B2) Rabbit mAb.

Phospho-α-E-Catenin (Ser655/Thr658) Antibody - 13231 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Phospho-α-E-Catenin (Ser655/Thr658) Antibody.

Phospho-α-E-Catenin (Ser652) Antibody - 13061 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Phospho-α-E-Catenin (Ser652) Antibody.

α E-catenin (1G5) - sc-47753 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
α-catenin (1G5): sc-47753. Western blot analysis of α-catenin expression in MCF7 whole cell lysate.

α E-catenin (C-19) - sc-1495 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
α E-catenin (C-19): sc-1495. Western blot analysis of α E-catenin expression in HeLa (A), A-431 (B) and RAW 264.7 (C) whole cell lysates.

α E-catenin (G-11) - sc-9988 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
α E-catenin (G-11): sc-9988. Immunofluorescence staining of methanol-fixed A-431 cells showing membrane staining.

α E-catenin (H-297) - sc-7894 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
α E-catenin (H-297): sc-7894. Western blot analysis of α E-catenin expression in HeLa (A) and A-431 (B) whole cell lysates.

p-α E-catenin (Ser 641) - sc-101824 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-alpha 1 Catenin (phospho S641) antibody - ab111587 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111587, at a 1/50 dilution, staining alpha 1 Catenin in paraffin embedded Human brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-alpha 1 Catenin antibody - ab11346 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab11346 staining alpha 1 Catenin (left) in Mouse cortical ventricular zone tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with 4% paraformaldehyde in PBS overnight at 4°C, then saturated in 30% sucrose at 4°C (for at least 18 hours). Fixed and saturated brains were embedded in OCT compound and frozen rapidly with dry ice, and then 12µm cyrosections collected and stored at -80°C. Samples were incubated with primary antibody (1/500). Middle - non-phosphorylated active beta catenin, Right - merge. Beta catenin co-localizes with alpha catenin at the apical adherens complexes of ventricular zone precursor cells.

Anti-alpha 1 Catenin antibody - ab48034 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
ab48034 at 3.8 µg/ml staining alpha 1 catenin in Human prostate tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-alpha 1 Catenin antibody - ab153721 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-alpha 1 Catenin antibody (ab153721) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : HeLa whole cell lysateLysates/proteins at 30 µg per lane.

Anti-alpha 1 Catenin antibody - ab6299 from Abcam

Prices $373.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-alpha 1 Catenin antibody - ab52227 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-alpha 1 Catenin antibody (ab52227) at 1/500 dilutionLane 1 : HeLa cell lysate Lane 2 : HeLa cell Lysate; ab52227 pre-incubated with immunising (blocking) peptide

Anti-alpha 1 Catenin antibody - ab37762 from Abcam

Prices $376.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-alpha 1 Catenin antibody (ab37762) at 1/2000 dilution + E. coli derived fusion protein at 2.5 µgSecondaryHRP conjugated Goat anti IgY at 1/1000 dilution

Anti-alpha 1 Catenin antibody [25B1] - ab49105 from Abcam

Prices $388.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 25B1
alpha 1 Catenin was immunoprecipitated using 0.5mg Hela whole cell extract, 5µg of Mouse monoclonal to and 50µl of protein G magnetic beads (+). No antibody was added to the control (-).The antibody was incubated under agitation with Protein G beads for 10min, Hela whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70°C; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab49105.Secondary: Goat polyclonal to mouse IgG light chain specific (HRP) at 1/20,000 dilution.Band: 100kDa; alpha 1 Catenin

Anti-alpha 1 Catenin antibody [EP1793Y] - ab51032 from Abcam

Prices $403.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1793Y
Anti-alpha 1 Catenin antibody [EP1793Y] (ab51032) at 1/50000 dilution + HeLa cell lysate at 10 µgSecondaryGoat anti-Rabbit HRP labeled at 1/2000 dilution

Anti-alpha 1 Catenin antibody - N-terminal - ab189310 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Kidney Tubules labeling alpha 1 Catenin with ab189310 at 5 µg/ml.

Anti-CTNNA1 Antibody (Internal) IHC-plus™ - LS-B4457 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
Anti-CTNNA1 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4457 concentration 3.75 ug/ml.

Anti-CTNNA1 Antibody (C-Terminus) - LS-C21235 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNNA1 Antibody - LS-C77779 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNNA1 Antibody (aa873-887) - LS-C77785 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNNA1 Antibody - LS-C95913 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CTNNA1 Antibody (Ser641) - LS-C51659 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of extracts from A431 cells untreated or treated with EGF (200 ng/ml, 30 min) using Rabbit Anti- alpha-Catenin (Ab-641) Polyclonal Antibody (LS-C51659, Lane 1 and 2) and Rabbit Anti- alpha-Catenin (Phospho-Ser641) Polyclonal Antibody
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