CTNNA1

Gene Symbol CTNNA1
Entrez Gene 1495
Alt Symbol CAP102
Species Human
Gene Type protein-coding
Description catenin (cadherin-associated protein), alpha 1, 102kDa
Other Description alpha E-catenin|alpha-E-catenin|alpha-catenin|alphaE-catenin|cadherin-associated protein,102kDa|catenin alpha-1|renal carcinoma antigen NY-REN-13
Swissprots Q8N1C0 Q12795 P35221
Accessions AAC99459 AAW56940 EAW62122 EAW62123 EAW62124 P35221 AI078507 AK055751 AK094151 BAG52830 AK296708 BAG59301 AK300439 BAG62162 AK304267 BAG65130 AU141929 BC000385 AAH00385 BC031262 AAH31262 BU624488 D13866 BAA02979 D14705 BAA03530 DA349847 DC369291 DQ891250 ABM82176 DQ894435 ABM85361 HQ589335 AEF32483 L22080 AAA35502 L23805 AAA86430 U03100 AAA18949 XM_005271899 XP_005271956 XM_006714536 XP_006714599 XM_011543172 XP_011541474 NM_001290307 NP_001277236 NM_001290309 NP_001277238 NM_001290310 NP_001277239 NM_001290312 NP_001277241 NM_001903 NP_001894
Function Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Subcellular Location Isoform 1: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.
Tissue Specificity Expressed ubiquitously in normal tissues.
Top Pathways Adherens junction, Tight junction, Leukocyte transendothelial migration, Endometrial cancer, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

CTNNA1-Over-expression-Lysate - LY10949a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag CTNNA1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CTNNA1 gene

CTNNA1 293 Cell Lysate - 400688 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Catenin alpha 1 Overexpression Lysate (Native) - NBL1-09575 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Catenin alpha 1 Overexpression Lysate (Adult Normal) [NBL1-09575] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Catenin alpha 1.

CTNNA1 Over-expression Lysate Product - GWB-712192 from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human CTNNA1 Knockdown Stable Cell Line - CSC-DC003798 from Creative biogene

Category Cell Line
Species Human

Human CTNNA1 Knockout Cell Line-HEK293T - CSC-RT1676 from Creative biogene

Category Cell Line
Species Human

CTNNA1 KO Cell Lysate-HEK293T - CLKO-1523 from Creative biogene

Category Cell Lysate
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