GOT1

Gene Symbol GOT1
Entrez Gene 2805
Alt Symbol ASTQTL1, GIG18, cAspAT, cCAT
Species Human
Gene Type protein-coding
Description glutamic-oxaloacetic transaminase 1, soluble
Other Description aspartate aminotransferase 1|aspartate aminotransferase, cytoplasmic|aspartate transaminase 1|cysteine aminotransferase, cytoplasmic|cysteine transaminase, cytoplasmic|glutamate oxaloacetate transaminase 1|growth-inhibiting protein 18|transaminase A
Swissprots Q5VW80 P17174 B7Z7E9 B2R6R7
Accessions AAC32851 CBF96059 CBV09579 EAW49868 EAW49869 P17174 AF052153 AAC28622 AK293483 BAH11518 AK301916 BAH13585 AK309174 AK312684 BAG35564 AY513279 AAT08032 BC000498 AAH00498 DA581933 EB387028 M37400 AAA35563 XR_945681 NM_002079 NP_002070
Function Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. {ECO:0000269|PubMed:16039064}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:1974457}.
Top Pathways Cysteine and methionine metabolism, Alanine, aspartate and glutamate metabolism, Phenylalanine metabolism, Tyrosine metabolism, Biosynthesis of amino acids

AATC CRISPR/Cas9 KO Plasmid (h) - sc-405477 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AATC HDR Plasmid (h) - sc-405477-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AATC Double Nickase Plasmid (h) - sc-405477-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AATC Double Nickase Plasmid (h2) - sc-405477-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AATC CRISPR Activation Plasmid (h) - sc-405477-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AATC CRISPR Activation Plasmid (h2) - sc-405477-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AATC Lentiviral Activation Particles (h) - sc-405477-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AATC Lentiviral Activation Particles (h2) - sc-405477-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AATC siRNA (h) - sc-45602 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AATC shRNA Plasmid (h) - sc-45602-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AATC shRNA (h) Lentiviral Particles - sc-45602-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU034261 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9491 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9491 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05676 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05676

GOT1 siRNA (Human) - CRH1875 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GOT1 - MBS8215100 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GOT1 (NM_002079.2) - SHH305482 from Creative biogene

Category siRNA
Species Reactivities Human

GOT1 shRNA Plasmid (Human) - CHH1875 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GOT1 miRNA 3'UTR clone - MiUTR3H-00877 from Creative biogene

Species Reactivities Human
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