EPHA1

Gene Symbol	EPHA1
Entrez Gene	2041
Alt Symbol	EPH, EPHT, EPHT1
Species	Human
Gene Type	protein-coding
Description	EPH receptor A1
Other Description	eph tyrosine kinase 1|ephrin type-A receptor 1|erythropoietin-producing hepatoma amplified sequence|erythropoietin-producing hepatoma receptor|hEpha1|oncogene EPH|soluble EPHA1 variant 1|soluble EPHA1 variant 2|tyrosine-protein kinase receptor EPH
Swissprots	Q15405 B5A966 B5A967 A1L3V3 P21709
Accessions	AAD43440 AAS07458 CCQ43308 EAL23789 EAW51845 EAW51846 EAW51847 P21709 AA723562 AA723620 AA788809 AI057542 AK290351 BAF83040 AK313263 AU131228 BC130291 AAI30292 BC144156 CD653381 CN289899 CN289901 EU826604 ACF47640 EU826605 ACF47641 M18391 AAA36747 Z27409 CAA81796 XM_006715880 XP_006715943 XM_011515878 XP_011514180 XR_428169 NM_005232 NP_005223
Function	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. {ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:19118217, ECO:0000269|PubMed:20043122}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19118217}; Single-pass type I membrane protein {ECO:0000269|PubMed:19118217}.
Tissue Specificity	Overexpressed in several carcinomas.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active Eph receptor A1 protein fragment - ab55900 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells

Active human Eph receptor A1 protein fragment - ab101778 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus Species Human

Human Eph receptor A1 protein fragment - ab158368 from Abcam Category Protein Source Wheat germ Species Human

EPHA1 / EPH Receptor A1 Antibody Blocking Peptide - LS-E3439 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHA1 / EPH Receptor A1 Antibody Blocking Peptide - LS-E9096 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHA1 / EPH Receptor A1 Antibody Blocking Peptide - LS-E9097 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human EphA1 Protein - H00002041-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EphA1 Peptide - P2616 from Novus Biologicals Category Peptide Species Human

EphA1 Peptide - P2615 from Novus Biologicals Category Peptide Species Human

EphA1-Antibody-C-term-Blocking-Peptide - BP7606b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EphA1-Antibody-N-term-Blocking-Peptide - BP7606a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Eph Protein Sampler Pack 1 - SMPK1 from R&D Systems Category Protein Prices $609.00 Sizes 1 pack

Eph Protein Sampler Pack 2 - SMPK2 from R&D Systems Category Protein Prices $509.00 Sizes 1 pack

Recombinant Human EphA1 Fc Chimera, CF - 7146-A1-100 from R&D Systems Category Protein Source Human embryonic kidney cell, HEK293-derived

Human EphA1 (His Tag) protein - orb232396 from Biorbyt Category Protein Prices $196.00, $323.00 Sizes 20 μg, 100 μg Species Human

Human EphA1 (Fc Tag) protein - orb232395 from Biorbyt Category Protein Prices $196.00, $323.00 Sizes 20 μg, 100 μg Species Human

EPHA1 (pY605) Blocking Peptide - abx161090 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Pig, Rabbit

Human EPHA1 Protein - abx066437 from Abbexa Category Protein Source E.coli Species Human

EPHA1 - H00002041-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EPHA1 - H00002041-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EPHA1 - P5545 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

EPHA1 fusion protein - ag19063 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human EPH Receptor A1 - EPHA1-1608H from Creative Biomart Category Protein Source NSO cells.

Recombinant Human EPH Receptor A1, GST-His - EPHA1-743H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human EPHA1 - EPHA1-28577TH from Creative Biomart Category Protein Source Baculovirus

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