EPHA1

Gene Symbol EPHA1
Entrez Gene 2041
Alt Symbol EPH, EPHT, EPHT1
Species Human
Gene Type protein-coding
Description EPH receptor A1
Other Description eph tyrosine kinase 1|ephrin type-A receptor 1|erythropoietin-producing hepatoma amplified sequence|erythropoietin-producing hepatoma receptor|hEpha1|oncogene EPH|soluble EPHA1 variant 1|soluble EPHA1 variant 2|tyrosine-protein kinase receptor EPH
Swissprots Q15405 B5A966 B5A967 A1L3V3 P21709
Accessions AAD43440 AAS07458 CCQ43308 EAL23789 EAW51845 EAW51846 EAW51847 P21709 AA723562 AA723620 AA788809 AI057542 AK290351 BAF83040 AK313263 AU131228 BC130291 AAI30292 BC144156 CD653381 CN289899 CN289901 EU826604 ACF47640 EU826605 ACF47641 M18391 AAA36747 Z27409 CAA81796 XM_006715880 XP_006715943 XM_011515878 XP_011514180 XR_428169 NM_005232 NP_005223
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. {ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:19118217, ECO:0000269|PubMed:20043122}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:19118217}; Single-pass type I membrane protein {ECO:0000269|PubMed:19118217}.
Tissue Specificity Overexpressed in several carcinomas.
Top Pathways Axon guidance

EphA1 CRISPR/Cas9 KO Plasmid (h) - sc-403340 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphA1 HDR Plasmid (h) - sc-403340-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphA1 Double Nickase Plasmid (h) - sc-403340-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphA1 Double Nickase Plasmid (h2) - sc-403340-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphA1 CRISPR Activation Plasmid (h) - sc-403340-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphA1 CRISPR Activation Plasmid (h2) - sc-403340-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphA1 Lentiviral Activation Particles (h) - sc-403340-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphA1 Lentiviral Activation Particles (h2) - sc-403340-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EphA1 siRNA (h) - sc-35318 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EphA1 shRNA Plasmid (h) - sc-35318-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EphA1 shRNA (h) Lentiviral Particles - sc-35318-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU017901 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK0672 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0674 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0673 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN7912 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7912 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03476 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03476

EPHA1 siRNA (Human) - CRH1418 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EphA1 RNAi - H00002041-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

EPHA1 - MBS8229894 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Epha1 (NM_005232.4) - SHH286333 from Creative biogene

Category siRNA
Species Reactivities Human

EPHA1 shRNA Plasmid (Human) - CHH1418 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EPHA1 miRNA 3'UTR clone - MiUTR3H-01996 from Creative biogene

Species Reactivities Human
Search more