Klk8

Gene Symbol Klk8
Entrez Gene 259277
Alt Symbol BSP1, Nrpn, Prss19
Species Mouse
Gene Type protein-coding
Description kallikrein related-peptidase 8
Other Description Brain Serine protease 1|NP|kallikrein 8|kallikrein-8|mK8|neuropsin|protease, serine, 19 (neuropsin)|serine protease 19
Swissprots Q8K5D7 Q61955
Accessions BAA92435 EDL22681 Q61955 AB074296 BAB92021 AB981040 BAQ21985 BC055895 AAH55895 D30785 BAA06451 XM_006540908 XP_006540971 NM_008940 NP_032966
Function Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269|PubMed:10762375, ECO:0000269|PubMed:11880192, ECO:0000269|PubMed:12944500, ECO:0000269|PubMed:16308352, ECO:0000269|PubMed:16537644, ECO:0000269|PubMed:17182622, ECO:0000269|PubMed:17629414, ECO:0000269|PubMed:9556608}.
Subcellular Location Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes.
Tissue Specificity Expressed in the limbic system of mouse brain and is localized at highest concentration in pyramidal neurons of the hippocampal CA1-3 subfields. Also detected in spinal cord gray matter and in keratinized stratified epithelia of epidermis, hair, tongue, palate, nasal cavity, pharynges, esophagus and forestomach. In skin and mucus membranes, expressed in stratum spinosum and stratum granulosum. Expressed during estrus in vaginal epithelial cells but not stromal cells. Within the vaginal epithelium, expressed in prickle cells, granular cells and parakeratotic cells but not in basal cells. Not expressed in uterus. Expressed in the keratinocytes. {ECO:0000269|PubMed:12354676, ECO:0000269|PubMed:17629414, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:7623137, ECO:0000269|PubMed:8602273, ECO:0000269|PubMed:9620300, ECO:0000269|PubMed:9749739}.

KLK8 (M-51) - sc-292341 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
KLK8 (M-51): sc-292341. Western blot analysis of KLK8 expression in mouse brain tissue extract (A) and H19-7/IGF-IR whole cell lysate (B).

KLK8 (Y-16) - sc-67667 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KLK8 (Y-16): sc-67667. Western blot analysis of KLK8 expression in mouse brain tissue extract.

KLK8 Polyclonal Antibody - bs-5871R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Rabbit Anti KLK8 Polyclonal Antibody, Unconjugated (bs-5871R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

KLK8 Antibody (OABF01618) - OABF01618 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SMAD1 antibody (Ser465) - 70R-30610 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Smad1 antibody (Ser465) - 70R-37368 from Fitzgerald

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SMAD1 antibody - 70R-30611 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-5871R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-5871R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-5871R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-5871R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, Cy3 Conjugated - bs-5871R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, Cy5 Conjugated - bs-5871R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, Cy5.5 Conjugated - bs-5871R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, Cy7 Conjugated - bs-5871R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, FITC Conjugated - bs-5871R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, Biotin Conjugated - bs-5871R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, HRP Conjugated - bs-5871R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SMAD1 antibody - 70R-50023 from Fitzgerald

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated - bs-5871R-A594 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated - bs-5871R-A680 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody, ALEXA FLUOR® 750 Conjugated - bs-5871R-A750 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody Cy3 Conjugated - C06067Cy3 from Signalway Antibody

Prices $409.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

KLK8 Polyclonal Antibody Cy5 Conjugated - C06067Cy5 from Signalway Antibody

Prices $409.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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