Klk8

Gene Symbol	Klk8
Entrez Gene	259277
Alt Symbol	BSP1, Nrpn, Prss19
Species	Mouse
Gene Type	protein-coding
Description	kallikrein related-peptidase 8
Other Description	Brain Serine protease 1|NP|kallikrein 8|kallikrein-8|mK8|neuropsin|protease, serine, 19 (neuropsin)|serine protease 19
Swissprots	Q8K5D7 Q61955
Accessions	BAA92435 EDL22681 Q61955 AB074296 BAB92021 AB981040 BAQ21985 BC055895 AAH55895 D30785 BAA06451 XM_006540908 XP_006540971 NM_008940 NP_032966
Function	Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269|PubMed:10762375, ECO:0000269|PubMed:11880192, ECO:0000269|PubMed:12944500, ECO:0000269|PubMed:16308352, ECO:0000269|PubMed:16537644, ECO:0000269|PubMed:17182622, ECO:0000269|PubMed:17629414, ECO:0000269|PubMed:9556608}.
Subcellular Location	Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes.
Tissue Specificity	Expressed in the limbic system of mouse brain and is localized at highest concentration in pyramidal neurons of the hippocampal CA1-3 subfields. Also detected in spinal cord gray matter and in keratinized stratified epithelia of epidermis, hair, tongue, palate, nasal cavity, pharynges, esophagus and forestomach. In skin and mucus membranes, expressed in stratum spinosum and stratum granulosum. Expressed during estrus in vaginal epithelial cells but not stromal cells. Within the vaginal epithelium, expressed in prickle cells, granular cells and parakeratotic cells but not in basal cells. Not expressed in uterus. Expressed in the keratinocytes. {ECO:0000269|PubMed:12354676, ECO:0000269|PubMed:17629414, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:7623137, ECO:0000269|PubMed:8602273, ECO:0000269|PubMed:9620300, ECO:0000269|PubMed:9749739}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse Kallikrein 8 Protein - abx067596 from Abbexa Category Protein Source E.coli Species Mouse

Kallikrein 8 (KLK8), Mouse - 20-6982 from ARP American Research Products Category Protein Prices $529.00 Sizes 50 µg Source E.coli Species Mouse

Recombinant Mothers Against Decapentaplegic Homolog 1 (Smad1) - RPA647Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Kallikrein-8(Klk8) - CSB-YP720268MO CSB-EP720268MO CSB-BP720268MO CSB-MP720268MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Recombinant Mouse KLK8 Protein - KLK8-8755M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

Klk8, 29-260aa, Mouse, His-tag, Baculovirus - ATGP3553 from ATGen Category Protein Prices $80.00, $240.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Mouse

Mouse Klk8 protein - orb54580 from Biorbyt Category Protein Prices $213.00, $408.00, $612.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Mouse

KLK8 Recombinant Protein (OPCD04708) - OPCD04708 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Kallikrein 8 (KLK8), Recombinant Protein - MBS2012417 from MyBioSource Category Protein Prices $195.00, $410.00, $635.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Kallikrein-8, Recombinant Protein - MBS146785 from MyBioSource Category Protein Prices $140.00, $205.00, $5,015.00 Sizes 2 µg, 10 µg, 1 mg Source Sf9, Baculovirus cells

Kallikrein-8 (Klk8), Recombinant Protein - MBS1436257 from MyBioSource Category Protein Prices $980.00, $980.00, $1,205.00, $1,205.00, $1,480.00, $1,480.00, $1,945.00, $1,945.00 Sizes 50 µg (Baculovirus), 500 µg (E-Coli), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Klk8, Recombinant Protein - MBS206559 from MyBioSource Category Protein Prices $310.00, $925.00 Sizes 50 µg, 250 µg Source Baculovirus Species Mouse

KLK8 Recombinant Protein (Mouse) (OPCA05068) - OPCA05068 from Aviva Systems Biology Category Protein Species Mouse

Recombinant Mouse Kallikrein-8 (Klk8) - RPC23159 from Biomatik Category Protein Prices $276.00, $505.00, $2,491.00 Sizes 50 µg, 100 µg, 1 mg Source E.coli Species Mouse

Recombinant Mouse Kallikrein-8 (Klk8) - RPC25410 from Biomatik Category Protein Prices $275.00, $503.00, $2,499.00 Sizes 50 µg, 100 µg, 1 mg Source Yeast Species Mouse

Mouse KLK8 protein - orb419098 from Biorbyt Category Protein Species Mouse

Recombinant Mouse KLK8 Protein (33-260 aa), His-tagged - KLK8-2157M from Creative Biomart Category Protein Source Yeast Species Mouse

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