| Gene Symbol | Klk8 |
|---|---|
| Entrez Gene | 259277 |
| Alt Symbol | BSP1, Nrpn, Prss19 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | kallikrein related-peptidase 8 |
| Other Description | Brain Serine protease 1|NP|kallikrein 8|kallikrein-8|mK8|neuropsin|protease, serine, 19 (neuropsin)|serine protease 19 |
| Swissprots | Q8K5D7 Q61955 |
| Accessions | BAA92435 EDL22681 Q61955 AB074296 BAB92021 AB981040 BAQ21985 BC055895 AAH55895 D30785 BAA06451 XM_006540908 XP_006540971 NM_008940 NP_032966 |
| Function | Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269|PubMed:10762375, ECO:0000269|PubMed:11880192, ECO:0000269|PubMed:12944500, ECO:0000269|PubMed:16308352, ECO:0000269|PubMed:16537644, ECO:0000269|PubMed:17182622, ECO:0000269|PubMed:17629414, ECO:0000269|PubMed:9556608}. |
| Subcellular Location | Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes. |
| Tissue Specificity | Expressed in the limbic system of mouse brain and is localized at highest concentration in pyramidal neurons of the hippocampal CA1-3 subfields. Also detected in spinal cord gray matter and in keratinized stratified epithelia of epidermis, hair, tongue, palate, nasal cavity, pharynges, esophagus and forestomach. In skin and mucus membranes, expressed in stratum spinosum and stratum granulosum. Expressed during estrus in vaginal epithelial cells but not stromal cells. Within the vaginal epithelium, expressed in prickle cells, granular cells and parakeratotic cells but not in basal cells. Not expressed in uterus. Expressed in the keratinocytes. {ECO:0000269|PubMed:12354676, ECO:0000269|PubMed:17629414, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:7623137, ECO:0000269|PubMed:8602273, ECO:0000269|PubMed:9620300, ECO:0000269|PubMed:9749739}. |