| Gene Symbol | DSC2 |
|---|---|
| Entrez Gene | 1824 |
| Alt Symbol | ARVD11, CDHF2, DG2, DGII/III, DSC3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | desmocollin 2 |
| Other Description | cadherin family member 2|desmocollin-2|desmosomal glycoprotein II/III |
| Swissprots | Q02487 |
| Accessions | ABM88172 CAL91822 CAL91823 EAX01250 EAX01251 Q02487 AK290313 BAF83002 AK297029 BAG59557 BC063291 AAH63291 BE350090 BE813598 BU735677 BX648425 CAH56152 CR749226 CAH18082 DC382631 EF017811 ABM88170 EF017812 ABM88171 X56807 CAA40141 XM_005258206 XP_005258263 NM_004949 NP_004940 NM_024422 NP_077740 |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:21062920}; Single-pass type I membrane protein {ECO:0000269|PubMed:21062920}. Cell junction, desmosome {ECO:0000269|PubMed:21062920}. |
| Tissue Specificity | Expressed in epithelia, myocardium and lymph nodes. |
| Top Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |