IKBKB

Gene Symbol	IKBKB
Entrez Gene	3551
Alt Symbol	IKK-beta, IKK2, IKKB, IMD15, NFKBIKB
Species	Human
Gene Type	protein-coding
Description	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Other Description	I-kappa-B kinase 2|I-kappa-B-kinase beta|IKK-B|inhibitor of nuclear factor kappa-B kinase subunit beta|nuclear factor NF-kappa-B inhibitor kinase beta
Swissprots	O14920 O75327 B4E0U4 B4DZ30
Accessions	AAT65965 EAW63222 EAW63223 EAW63224 EAW63225 EAW63226 O14920 AB209090 BAD92327 AF029684 AAC51860 AF031416 AAC64675 AF080158 AAD08997 AI379342 AK091090 AK091297 BAG52329 AK093537 AK095687 AK097828 AK290952 BAF83641 AK298241 BAG60507 AK302723 BAG63942 AK303294 BAG64369 AK303528 BAG64556 AK316418 BAH14789 AL708460 BC006231 AAH06231 BC090865 BC108694 AAI08695 BC127663 AAI27664 BC141978 AAI41979 BC144080 BX648165 DA043516 DA105584 DA159382 DA709000 XM_005273490 XP_005273547 XM_005273491 XP_005273548 XM_005273492 XP_005273549 XM_005273493 XP_005273550 XM_005273494 XP_005273551 XM_005273495 XP_005273552 XM_005273496 XP_005273553 XM_005273498 XP_005273555 XM_011544517 XP_011542819 XM_011544518 XP_011542820 XM_011544519 XP_011542821 XM_011544520 XP_011542822 XM_011544521 XP_011542823 XM_011544522 XP_011542824 XR_949402 NM_001190720 NP_001177649 NM_001242778 NP_001229707 NM_001556 NP_001547 NR_033818 NR_033819 NR_040009 NM_001190721 NM_001190722
Function	Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since t
Subcellular Location	Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Tissue Specificity	Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
Top Pathways	HTLV-I infection, Osteoclast differentiation, RIG-I-like receptor signaling pathway, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-IKKβ (Ser177/181) Sandwich ELISA Kit - 7080 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

HTScan® IKKβ Kinase Assay Kit - 7549 from Cell Signaling Technology Category Assay Kit

Mouse IKBKB / IKK2 / IKK Beta ELISA Kit (Sandwich ELISA) - LS-F6839 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-IKBKB / IKK2 / IKK Beta (Tyr188) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1144 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat IKBKB / IKK2 / IKK Beta ELISA Kit (Cell-Based ELISA) - LS-F2072 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-IKBKB / IKK2 / IKK Beta (Tyr199) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1173 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Human IKBKB / IKK2 / IKK Beta ELISA Kit (Sandwich ELISA) - LS-F8874 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Rabbit anti-IKK-beta Antibody, Affinity Purified - PLA0218 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb), Human, ELISA Kit - SEJ822Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.063ng/mL Range 0.156-10ng/mL

Inhibitor of nuclear factor kappa-B kinase subunit beta, IKBKB, Human, ELISA Kit - E1953h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 1.56-100 ng/mL

IKBKB (Human) Matched Antibody Pair - H00000334-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb), ELISA Kit - MBS2019397 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.059ng/mL. Range 0.156-10ng/mL

Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb), ELISA Kit - MBS9307252 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb), ELISA Kit - MBS2023657 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of IkBKb is typically less than 0.059ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.156-10ng/mL

IKK-beta Colorimetric Cell-Based ELISA Kit - CB5359 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

IKK-beta (Phospho-Tyr188) Colorimetric Cell-Based ELISA Kit - CBP1128 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

IKK-beta (Phospho-Tyr199) Colorimetric Cell-Based ELISA Kit - CBP1162 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Inhibitor K Binding, ELISA Kit - MBS052044 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor K Binding, ELISA Kit - MBS035966 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor K Binding, ELISA Kit - MBS033420 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor K Binding, ELISA Kit - MBS030357 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor K Binding, ELISA Kit - MBS021405 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor K Binding, ELISA Kit - MBS039853 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor K Binding, ELISA Kit - MBS033974 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor K Binding, ELISA Kit - MBS031933 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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