IKBKB

Gene Symbol IKBKB
Entrez Gene 3551
Alt Symbol IKK-beta, IKK2, IKKB, IMD15, NFKBIKB
Species Human
Gene Type protein-coding
Description inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Other Description I-kappa-B kinase 2|I-kappa-B-kinase beta|IKK-B|inhibitor of nuclear factor kappa-B kinase subunit beta|nuclear factor NF-kappa-B inhibitor kinase beta
Swissprots O14920 O75327 B4E0U4 B4DZ30
Accessions AAT65965 EAW63222 EAW63223 EAW63224 EAW63225 EAW63226 O14920 AB209090 BAD92327 AF029684 AAC51860 AF031416 AAC64675 AF080158 AAD08997 AI379342 AK091090 AK091297 BAG52329 AK093537 AK095687 AK097828 AK290952 BAF83641 AK298241 BAG60507 AK302723 BAG63942 AK303294 BAG64369 AK303528 BAG64556 AK316418 BAH14789 AL708460 BC006231 AAH06231 BC090865 BC108694 AAI08695 BC127663 AAI27664 BC141978 AAI41979 BC144080 BX648165 DA043516 DA105584 DA159382 DA709000 XM_005273490 XP_005273547 XM_005273491 XP_005273548 XM_005273492 XP_005273549 XM_005273493 XP_005273550 XM_005273494 XP_005273551 XM_005273495 XP_005273552 XM_005273496 XP_005273553 XM_005273498 XP_005273555 XM_011544517 XP_011542819 XM_011544518 XP_011542820 XM_011544519 XP_011542821 XM_011544520 XP_011542822 XM_011544521 XP_011542823 XM_011544522 XP_011542824 XR_949402 NM_001190720 NP_001177649 NM_001242778 NP_001229707 NM_001556 NP_001547 NR_033818 NR_033819 NR_040009 NM_001190721 NM_001190722
Function Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since t
Subcellular Location Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Tissue Specificity Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
Top Pathways HTLV-I infection, Osteoclast differentiation, RIG-I-like receptor signaling pathway, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer

IKBKB-Over-expression-Lysate - LY10108a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag IKBKB (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the IKBKB gene (Lane 2, Cat. #LY10108a).

IKBKB 293T Cell Transient Overexpression Lysate(Denatured) - H00003551-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

IKBKB overexpression lysate - LY419865 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

IKK beta Overexpression Lysate (Denatured) - H00003551-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Lane 1: IKBKB transfected lysate (28.27 KDa) Lane 2: Non-transfected lysate.

IKKβ (h): 293T Lysate - sc-112055 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

IKK beta Overexpression Lysate (Native) - NBP2-10983 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg

IKBKB-knockout Cell lysate - LC810115 from Acris Antibodies

Category Cell Lysate
Prices $495.00
Sizes 100 µg

Panoply™ Human IKBKB Knockdown Stable Cell Line - CSC-DC007520 from Creative biogene

Category Cell Line
Species Human

Human IKBKB Knockout Cell Line-HeLa - CSC-RT0713 from Creative biogene

Category Cell Line
Species Human

IKBKB KO Cell Lysate-HeLa - CLKO-0218 from Creative biogene

Category Cell Lysate
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