IKBKB

Gene Symbol IKBKB
Entrez Gene 3551
Alt Symbol IKK-beta, IKK2, IKKB, IMD15, NFKBIKB
Species Human
Gene Type protein-coding
Description inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Other Description I-kappa-B kinase 2|I-kappa-B-kinase beta|IKK-B|inhibitor of nuclear factor kappa-B kinase subunit beta|nuclear factor NF-kappa-B inhibitor kinase beta
Swissprots O14920 O75327 B4E0U4 B4DZ30
Accessions AAT65965 EAW63222 EAW63223 EAW63224 EAW63225 EAW63226 O14920 AB209090 BAD92327 AF029684 AAC51860 AF031416 AAC64675 AF080158 AAD08997 AI379342 AK091090 AK091297 BAG52329 AK093537 AK095687 AK097828 AK290952 BAF83641 AK298241 BAG60507 AK302723 BAG63942 AK303294 BAG64369 AK303528 BAG64556 AK316418 BAH14789 AL708460 BC006231 AAH06231 BC090865 BC108694 AAI08695 BC127663 AAI27664 BC141978 AAI41979 BC144080 BX648165 DA043516 DA105584 DA159382 DA709000 XM_005273490 XP_005273547 XM_005273491 XP_005273548 XM_005273492 XP_005273549 XM_005273493 XP_005273550 XM_005273494 XP_005273551 XM_005273495 XP_005273552 XM_005273496 XP_005273553 XM_005273498 XP_005273555 XM_011544517 XP_011542819 XM_011544518 XP_011542820 XM_011544519 XP_011542821 XM_011544520 XP_011542822 XM_011544521 XP_011542823 XM_011544522 XP_011542824 XR_949402 NM_001190720 NP_001177649 NM_001242778 NP_001229707 NM_001556 NP_001547 NR_033818 NR_033819 NR_040009 NM_001190721 NM_001190722
Function Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since t
Subcellular Location Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Tissue Specificity Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
Top Pathways HTLV-I infection, Osteoclast differentiation, RIG-I-like receptor signaling pathway, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer

Active human IKK beta full length protein - ab125564 from Abcam

Category Protein
Prices $342.00
Sizes 5 µg
Source Baculovirus infected sf9 cells
Species Human
SDS-PAGE analysis of ab125564.

Active human IKK beta full length protein - ab177584 from Abcam

Category Protein
Prices $251.00
Sizes 5 µg
Source Baculovirus infected sf9 cells
Species Human
The purity of ab177584 was determined to be >95% by densitometry.

Human IKK beta full length protein - ab114243 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE showing ab114243 at approximately 53.79kDa stained with Coomassie Blue.

Human IKK beta protein fragment - ab158754 from Abcam

Category Protein
Source Wheat germ
Species Human
ab158754 on a 12.5% SDS-PAGE stained with Coomassie Blue.

IKK beta peptide - ab154148 from Abcam

Category Peptide

IKK beta peptide - ab7895 from Abcam

Category Peptide

IKK beta peptide - ab7612 from Abcam

Category Peptide

IKBKB / IKK2 / IKK Beta Antibody Blocking Peptide - LS-E7514 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IKBKB / IKK2 / IKK Beta Antibody Blocking Peptide - LS-E7515 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IKBKB / IKK2 / IKK Beta Antibody Blocking Peptide - LS-E7517 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IKBKB / IKK2 / IKK Beta Antibody Blocking Peptide - LS-E7516 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IKBKB / IKK2 / IKK Beta Antibody Blocking Peptide - LS-E7518 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IKBKB / IKK2 / IKK Beta Antibody Blocking Peptide - LS-E7546 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IKBKB / IKK2 / IKK Beta Antibody Blocking Peptide - LS-E7279 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IKBKB / IKK2 / IKK Beta Antibody Blocking Peptide - LS-E11476 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IKBKB / IKK2 / IKK Beta Antibody Blocking Peptide - LS-E11174 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

IKBKB / IKK2 / IKK Beta Antibody Blocking Peptide - LS-E29892 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

IKK beta Partial Recombinant Protein - H00003551-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

IKK beta Recombinant Protein - H00003551-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

Recombinant Human IKK beta Protein - P4703 from Novus Biologicals

Category Protein
Prices $1,559.00
Sizes 100 µg
Source Insect
Species Human

IKK beta Blocking Peptide - NB600-477PEP from Novus Biologicals

Category Peptide
Prices $169.00
Sizes 50 µg
Species Human

IKK beta Blocking Peptide - NBP1-76935PEP from Novus Biologicals

Category Peptide
Prices $129.00
Sizes 50 µg
Species Human

IKK beta Peptide - P1333 from Novus Biologicals

Category Peptide
Species Human

IKKB-Antibody-C-term-S675-Blocking-Peptide - BP19041b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

IKKB-Antibody-C-term-S670S672-Blocking-Peptide - BP18900b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg
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