CASP1

Gene Symbol CASP1
Entrez Gene 834
Alt Symbol ICE, IL1BC, P45
Species Human
Gene Type protein-coding
Description caspase 1, apoptosis-related cysteine peptidase
Other Description CASP1 nirs variant 1|IL-1 beta-converting enzyme|IL1B-convertase|caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)|caspase-1|interleukin 1, beta, convertase|interleukin 1-B converting enzyme
Swissprots P29466 Q9UCN3 Q6PI75 Q6GSS3 Q53EY6 B5MDZ1 Q6DMQ1
Accessions AAD15243 EAW67057 EAW67058 EAW67059 EAW67060 EAW67061 P29466 AA505065 AA737419 AA761907 AB102878 BAD89407 AK223503 BAD97223 AK290114 BAF82803 AK290122 BAF82811 AK296646 BAG59246 AK301037 BAG62650 AK310059 AK313516 BAG36296 AY660536 AAT72297 BC041689 AAH41689 BC062327 AAH62327 HQ447656 ADQ32141 M87507 AAA66942 U13697 AAC50107 U13698 AAC50108 U13699 AAC50109 U13700 AAC50110 X65019 CAA46153 XM_006718924 XP_006718987 XM_011543017 XP_011541319 XM_011543018 XP_011541320 NM_001223 NP_001214 NM_001257118 NP_001244047 NM_001257119 NP_001244048 NM_033292 NP_150634 NM_033293 NP_150635 NM_033294 NP_150636 NM_033295 NP_150637
Function Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. {ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:7876192}.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. {ECO:0000269|PubMed:15498465}.
Top Pathways Amyotrophic lateral sclerosis (ALS), NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Pertussis, Influenza A

Cleaved Caspase-1 (Asp297) (D57A2) Rabbit mAb - 4199 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D57A2
Western blot analysis of extracts from COS-7 cells, untransfected () or transfected with construct overexpressing human caspase-1 (+), using Cleaved Caspase-1 (Asp297) (D57A2) Rabbit mAb (upper) or Caspase-1 (D7F10) Rabbit mAb #3866 (lower).

Caspase-1 (D7F10) Rabbit mAb - 3866 from Cell Signaling Technology

Prices $99.00, $261.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7F10
Western blot analysis of extracts from THP-1 and NK-92 cells using Caspase-1 (D7F10) Rabbit mAb.

Caspase-1 Antibody - 2225 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from THP-1 and HL-60 cells, using Caspase-1 Antibody.

caspase-1 (A-19) - sc-622 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of caspase-1 (ICE) expression in HL-60 cells treated for zero (A,F), one (B,G), two (C,H), three (D,I) or four (E,J) hours with LPS. Antibodies tested include caspase-1 p10 (C-20): sc-515 (A-E) and caspase-1 (A-19): sc-622 (F-J).

caspase-1 (14F468) - sc-56036 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
caspase-1 (14F468): sc-56036. Western blot analysis of caspase-1 expression in HL-60 (A), LPS-treated HL-60 (B) and THP-1 (C) whole cell lysates.

caspase-1 p10 (C-20) - sc-515 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
caspase-1 p10 (C-20): sc-515. Western blot analysis of caspase-1 p10 expression in WI 38 (A) and H69AR (B) whole cell lysates.

caspase-1 p20 (C-15) - sc-1780 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
caspase-1 p20 (C-15): sc-1780. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing cytoplasmic and nuclear staining of urothelial cells.

cleaved caspase-1 p10 (h317) - sc-22164 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

cleaved caspase-1 p20 (h297) - sc-22163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

caspase-1 (D-3) - sc-392736 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-1 (D-3): sc-392736. Western blot analysis of caspase-1 expression in human spleen tissue extract (A) and THP-1 (B), HL-60 (C) and LPS treated HL-60 (D) whole cell lysates.

Anti-Caspase-1 (phospho S376) antibody - ab61794 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caspase-1 (phospho S376) antibody (ab61794) at 1/500 dilutionLane 1 : 293 cell extractsLane 2 : 293 cell extracts with immunising peptide

Anti-Caspase-1 antibody - ab1872 from Abcam

Prices $384.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab1872 staining Caspase-1 in mouse immortalised bone marrow-derived macrophages by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde, permeabilized with Triton X-100 (0.1%) and blocked with 5% serum for 1 hour at 20°C. Samples were incubated with primary antibody (1:200 in PBS + 0.1% BSA/5% goat serum) for 1 hour at 20°C. An anti-rabbit Alexa Fluor®568 (1/500) ab175471) was used as the secondary antibody.See Abreview

Anti-Caspase-1 antibody - ab62399 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Caspase-1 antibody (ab62399) at 0.5 µg/mlLane 2 : Anti-Caspase-1 antibody (ab62399) at 1 µg/mlLane 3 : Anti-Caspase-1 antibody (ab62399) at 2 µg/mlLane 1 : HeLa cell lysateLane 2 : HeLa cell lysateLane 3 : HeLa cell lysate

Anti-Caspase-1 antibody - ab54932 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Caspase-1 antibody (ab54932) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human hepatocellular carcinoma.

Anti-Caspase-1 antibody - ab62698 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62698 at a 1:50 dilution, staining Caspase-1 in paraffin embedded human brain tissue by Immunohistochemsitry in the absence (left image) or presence (right image) of the immunising peptide.

Anti-Caspase-1 antibody - ab74279 from Abcam

Prices $378.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab74279, at 1:50 dilution, staining Caspase-1 in formalin-fixed, paraffin-embedded human placenta tissue by immunohistochemistry.

Anti-Caspase-1 antibody - ab7978 from Abcam

Prices $372.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal

Anti-Caspase-1 antibody - ab82563 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caspase-1 antibody (ab82563) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Spleen (Human) Tissue Lysate - adult normal tissue (ab29699)Lane 3 : Lung (Human) Tissue LysateLane 4 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell LysateLane 5 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 6 : Caco 2 (Human colonic carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Caspase-1 antibody - ab14368 from Abcam

Prices $359.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Caspase-1 antibody (ab14368) at 0.5 µg/ml + Cell lysates prepared from Hela cellsWestern blot analysis of Caspase-1 in HeLa cell lysate using ab14368 at 0.5 ug/ml.

Anti-Caspase-1 antibody [14F468] - ab14367 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 14F468
Immunohistochemical analysis of formalin-fixed, paraffin embedded normal Human lung tissue labeling Caspase 1 with ab14367 at 5 ug/ml. In this representative lung section, different type of cells including pseudostratified columnar epithelium of bronchiole and the simple squamous epithelium of alveoli may be seen to develop immunoreactivity for Caspase 1. [10X Magnification]

Anti-Caspase-1 antibody [EPR4321] - ab108362 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4321
All lanes : Anti-Caspase-1 antibody [EPR4321] (ab108362) at 1/10000 dilution (purified)Lane 1 : THP-1 cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP goat anti-rabbit at 1/1000 dilution

Anti-Caspase-1 antibody, prediluted - ab15550 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab15550 staining Caspase-1 in human placenta by Immunohistochemistry (FFPE-sections).

Anti-Caspase-1 antibody [SB122a] - ab87018 from Abcam

Host Rat
Clonality Monoclonal
Clone SB122a
Anti-Caspase-1 antibody [SB122a] (ab87018) at 5 µg/ml + Jurkat cell lysate stimulated with an anit DR5 antibodySecondaryHRP-conjugated Goat anti-Rat IgG(H+L)Observed band size : 45 kDa (why is the actual band size different from the predicted?)

Anti-Caspase-1 antibody - N-terminal - ab189796 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Caspase-1 antibody - N-terminal (ab189796) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractsLane 2 : Jurkat total cell extracts

Anti-CASP1 / Caspase 1 Antibody (aa225-242) - LS-C21288 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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