CASP1

Gene Symbol	CASP1
Entrez Gene	834
Alt Symbol	ICE, IL1BC, P45
Species	Human
Gene Type	protein-coding
Description	caspase 1, apoptosis-related cysteine peptidase
Other Description	CASP1 nirs variant 1|IL-1 beta-converting enzyme|IL1B-convertase|caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)|caspase-1|interleukin 1, beta, convertase|interleukin 1-B converting enzyme
Swissprots	P29466 Q9UCN3 Q6PI75 Q6GSS3 Q53EY6 B5MDZ1 Q6DMQ1
Accessions	AAD15243 EAW67057 EAW67058 EAW67059 EAW67060 EAW67061 P29466 AA505065 AA737419 AA761907 AB102878 BAD89407 AK223503 BAD97223 AK290114 BAF82803 AK290122 BAF82811 AK296646 BAG59246 AK301037 BAG62650 AK310059 AK313516 BAG36296 AY660536 AAT72297 BC041689 AAH41689 BC062327 AAH62327 HQ447656 ADQ32141 M87507 AAA66942 U13697 AAC50107 U13698 AAC50108 U13699 AAC50109 U13700 AAC50110 X65019 CAA46153 XM_006718924 XP_006718987 XM_011543017 XP_011541319 XM_011543018 XP_011541320 NM_001223 NP_001214 NM_001257118 NP_001244047 NM_001257119 NP_001244048 NM_033292 NP_150634 NM_033293 NP_150635 NM_033294 NP_150636 NM_033295 NP_150637
Function	Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. {ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:7876192}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. {ECO:0000269|PubMed:15498465}.
Top Pathways	Amyotrophic lateral sclerosis (ALS), NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Pertussis, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Caspase Family Colorimetric Substrate Kit Plus - ab102486 from Abcam Category Cellular Assay Prices $618.00 Sizes 25 tests

Human CASP1 / Caspase 1 ELISA Kit (Sandwich ELISA) - LS-F4802 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 15.6-1000 pg/ml

Rat CASP1 / Caspase 1 ELISA Kit (Sandwich ELISA) - LS-F6716 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.112 ng/ml Range 15.6-1000 pg/ml

Mouse/Human/Rat CASP1 / Caspase 1 ELISA Kit (Cell-Based ELISA) - LS-F1851 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 15.6-1000 pg/ml

Mouse/Human/Rat Phospho-CASP1 / Caspase 1 (Ser376) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1384 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 15.6-1000 pg/ml

Mouse CASP1 / Caspase 1 ELISA Kit (Sandwich ELISA) - LS-F9042 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 13.5 pg/ml Range 15.6-1000 pg/ml

Human CASP1 / Caspase 1 ELISA Kit (Sandwich ELISA) - LS-F11012 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 15.6 Range 15.6-1000 pg/ml

Caspase-1 Fluorometric Assay Kit - KA0729 from Novus Biologicals Category Assay Kit Prices $659.00 Sizes 1 kit

Caspase-1 Fluorometric Assay Kit - KA0728 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

Caspase-1 Colorimetric Assay Kit - KA0727 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

Human Caspase-1/ICE Quantikine ELISA Kit - DCA100 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 1.24 pg/mL Range 6.3 - 400 pg/mL (Cell Culture Supernates)

Quantikine Immunoassay Control Set 775 Human Caspase-1/ICE - QC57 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Caspase 1, CASP1, Human, ELISA Kit - E-EL-H0016 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 46.875 Range 78.125-5000pg/mL

Caspase-1, CASP1, Human, ELISA Kit - E1592h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 15.6-1000 pg/mL

Caspase 1, CASP1, Mouse, ELISA Kit - E-EL-M0201 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Caspase 1, CASP1, Rat, ELISA Kit - E-EL-R0371 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Caspase 1, CASP1, Rabbit, ELISA Kit - E-EL-RB2148 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Caspase 1, CASP1, Chicken, ELISA Kit - E-EL-Ch1068 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Caspase 1, CASP1, Porcine, ELISA Kit - E-EL-P0545 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

Caspase 1, CASP1, Sheep, ELISA Kit - E-EL-S0875 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Caspase 1, CASP1, Guinea Pig, ELISA Kit - E-EL-GP0742 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Caspase 1, CASP1, Monkey, ELISA Kit - E-EL-MK0446 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Anserine Caspase-1/ICE ELISA Kit - AC0696 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Caspase 1 Colorimetric Cell-Based ELISA Kit - CB5098 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Caspase 1 (Phospho-Ser376) Colorimetric Cell-Based ELISA Kit - CBP1403 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

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