CASP1

Gene Symbol CASP1
Entrez Gene 834
Alt Symbol ICE, IL1BC, P45
Species Human
Gene Type protein-coding
Description caspase 1, apoptosis-related cysteine peptidase
Other Description CASP1 nirs variant 1|IL-1 beta-converting enzyme|IL1B-convertase|caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)|caspase-1|interleukin 1, beta, convertase|interleukin 1-B converting enzyme
Swissprots P29466 Q9UCN3 Q6PI75 Q6GSS3 Q53EY6 B5MDZ1 Q6DMQ1
Accessions AAD15243 EAW67057 EAW67058 EAW67059 EAW67060 EAW67061 P29466 AA505065 AA737419 AA761907 AB102878 BAD89407 AK223503 BAD97223 AK290114 BAF82803 AK290122 BAF82811 AK296646 BAG59246 AK301037 BAG62650 AK310059 AK313516 BAG36296 AY660536 AAT72297 BC041689 AAH41689 BC062327 AAH62327 HQ447656 ADQ32141 M87507 AAA66942 U13697 AAC50107 U13698 AAC50108 U13699 AAC50109 U13700 AAC50110 X65019 CAA46153 XM_006718924 XP_006718987 XM_011543017 XP_011541319 XM_011543018 XP_011541320 NM_001223 NP_001214 NM_001257118 NP_001244047 NM_001257119 NP_001244048 NM_033292 NP_150634 NM_033293 NP_150635 NM_033294 NP_150636 NM_033295 NP_150637
Function Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. {ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:7876192}.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. {ECO:0000269|PubMed:15498465}.
Top Pathways Amyotrophic lateral sclerosis (ALS), NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Pertussis, Influenza A

caspase-1 CRISPR/Cas9 KO Plasmid (h) - sc-417320 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-1 HDR Plasmid (h) - sc-417320-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-1 Double Nickase Plasmid (h) - sc-417320-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-1 Double Nickase Plasmid (h2) - sc-417320-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-1 CRISPR Activation Plasmid (h) - sc-417320-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-1 CRISPR Activation Plasmid (h2) - sc-417320-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-1 Lentiviral Activation Particles (h) - sc-417320-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-1 Lentiviral Activation Particles (h2) - sc-417320-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

caspase-1 siRNA (h) - sc-29235 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caspase-1 shRNA Plasmid (h) - sc-29235-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caspase-1 shRNA (h) Lentiviral Particles - sc-29235-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caspase-1 siRNA (h2) - sc-156046 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caspase-1 shRNA Plasmid (h2) - sc-156046-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

caspase-1 shRNA (h2) Lentiviral Particles - sc-156046-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Caspase-1 RNAi - H00000834-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Caspase-1 RNAi - H00000834-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Caspase-1 RNAi - H00000834-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Caspase-1 RNAi - H00000834-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU097671 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1967 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1967 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CASP1 siRNA (Human) - CRH0588 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Caspase-1 RNAi - H00000834-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CASP1 - MBS8208816 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Caspase 1 - MBS826809 from MyBioSource

Prices $255.00
Sizes 5 od
Species Reactivities Human
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