BIRC3

Gene Symbol BIRC3
Entrez Gene 330
Alt Symbol AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2
Species Human
Gene Type protein-coding
Description baculoviral IAP repeat containing 3
Other Description IAP homolog C|IAP-1|RING finger protein 49|TNFR2-TRAF signaling complex protein|TNFR2-TRAF-signaling complex protein 1|apoptosis inhibitor 2|baculoviral IAP repeat-containing 3|baculoviral IAP repeat-containing protein 3|inhibitor of apoptosis protein 1|mammalian IAP homolog C
Swissprots Q9HC27 Q9UP46 Q13489 Q16628
Accessions AAG09369 AAU88144 CBX47599 CBX47600 EAW67017 Q13489 AA805622 AA873008 AF070674 AAC83232 AI880555 BC027485 BC037420 AAH37420 BE907592 BG569841 BQ718651 BU428906 BX415415 BX475964 L43346 L49432 AAC41943 U37546 AAC50507 U45878 AAC50371 XM_011542797 XP_011541099 NM_001165 NP_001156 NM_182962 NP_892007
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex tha
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15665297}. Nucleus {ECO:0000269|PubMed:15665297}.
Tissue Specificity Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
Top Pathways NOD-like receptor signaling pathway, TNF signaling pathway, Toxoplasmosis, Apoptosis, Small cell lung cancer

c-IAP2 (58C7) Rabbit mAb - 3130 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 58C7
Western blot analysis of extracts from Raji, Ramos and SR cell lines, using c-IAP2 (58C7) Rabbit mAb.

c-IAP2 (F-20) - sc-1957 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
c-IAP2 (F-20): sc-1957. Western blot analysis of c-IAP2 expression in U-937 whole cell lysate.

c-IAP2 (H-85) - sc-7944 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
c-IAP2 (H-85): sc-7944. Western blot analysis of c-IAP2 expression in HeLa (A) and A-431 (B) whole cell lysates.

Anti-cIAP2 antibody - ab23423 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab23423 stained human HeLa cells. The cells were methanol fixed (5 min) and incubated with the antibody (ab23423, 1µg/ml) for 1h at room temperature. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Image-iTTM FX Signal Enhancer was used as the primary blocking agent, 5% BSA (in TBS-T) was used for all other blocking steps. DAPI was used to stain the cell nuclei (blue). Alexa Fluor® 594 WGA was used to label plasma membranes (red).

Anti-cIAP2 antibody - ab137393 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-cIAP2 antibody (ab137393) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLane 3 : H1299 whole cell lysateLane 4 : HeLa whole cell lysateLane 5 : HepG2 whole cell lysateLane 6 : MOLT4 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-cIAP2 antibody - ab2540 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-cIAP2 antibody - ab113237 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-cIAP2 antibody (ab113237) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLane 3 : H1299 whole cell lysateLane 4 : HeLa whole cell lysateLane 5 : HepG2 whole cell lysateLane 6 : MOLT4 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-cIAP2 antibody - ab116530 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-cIAP2 antibody (ab116530) at 1/100 dilution + MDA-MB435 cell line lysate at 35 µg

Anti-cIAP2 antibody - ab109549 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-cIAP2 antibody (ab109549) at 1 µg/ml + Rat testis lysate at 35 µg

Anti-cIAP2 antibody - ab171795 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-cIAP2 antibody (ab171795) at 1 µg/mlLane 1 : cIAP2 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilutiondeveloped using the ECL technique

Anti-cIAP2 antibody [E40] - ab32059 from Abcam

Prices $401.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E40
Anti-cIAP2 antibody [E40] (ab32059) at 1/1000 dilution + Daudi cell lysate.

Anti-BIRC3 / cIAP2 Antibody - LS-C77054 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-BIRC3 / cIAP2 Antibody (aa152-172) - LS-C77056 from LifeSpan Bioscience

Prices $575.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-BIRC3 / cIAP2 Antibody (aa100-200, Biotin) - LS-C143142 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BIRC3 / cIAP2 Antibody (aa100-200, DY488) - LS-C143144 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BIRC3 / cIAP2 Antibody (aa100-200, HRP) - LS-C143145 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BIRC3 / cIAP2 Antibody (aa100-200, DY650) - LS-C143143 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BIRC3 / cIAP2 Antibody (aa100-200, DY550) - LS-C143146 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BIRC3 / cIAP2 Antibody - LS-C149194 from LifeSpan Bioscience

Prices $305.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-BIRC3 / cIAP2 Antibody (Internal) - LS-C142732 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
cIAP2/HIAD1 Antibody - IHC of human adenocarcinoma cells and adjacent glands using anti-cIAP2.

Anti-BIRC3 / cIAP2 Antibody (aa2-604, clone 1D4B) - LS-C189776 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D4B

Anti-BIRC3 / cIAP2 Antibody IHC-plus™ - LS-B5024 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-cIAP2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5024 concentration 5 ug/ml.

Anti-BIRC3 / cIAP2 Antibody (aa532-549) - LS-C148260 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
IHC of cIAP2 in paraffin-embedded formalin-fixed human mammary gland (female breast) using LS-C148260 at 1:2000. A, normal breast tissue. B, ductal carcinoma in situ (DCIS). C. invasive neoplasia. cIAP2 expressed increased successively with tumor progression. Hematoxylin-Eosin counterstain.

Anti-BIRC3 / cIAP2 Antibody (clone E40) IHC-plus™ - LS-B7786 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone E40
Anti-BIRC3 / cIAP2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7786 dilution 1:50.

Anti-BIRC3 / cIAP2 Antibody (aa59-88, AP) - LS-C252584 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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