BIRC3

Gene Symbol BIRC3
Entrez Gene 330
Alt Symbol AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2
Species Human
Gene Type protein-coding
Description baculoviral IAP repeat containing 3
Other Description IAP homolog C|IAP-1|RING finger protein 49|TNFR2-TRAF signaling complex protein|TNFR2-TRAF-signaling complex protein 1|apoptosis inhibitor 2|baculoviral IAP repeat-containing 3|baculoviral IAP repeat-containing protein 3|inhibitor of apoptosis protein 1|mammalian IAP homolog C
Swissprots Q9HC27 Q9UP46 Q13489 Q16628
Accessions AAG09369 AAU88144 CBX47599 CBX47600 EAW67017 Q13489 AA805622 AA873008 AF070674 AAC83232 AI880555 BC027485 BC037420 AAH37420 BE907592 BG569841 BQ718651 BU428906 BX415415 BX475964 L43346 L49432 AAC41943 U37546 AAC50507 U45878 AAC50371 XM_011542797 XP_011541099 NM_001165 NP_001156 NM_182962 NP_892007
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex tha
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15665297}. Nucleus {ECO:0000269|PubMed:15665297}.
Tissue Specificity Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
Top Pathways NOD-like receptor signaling pathway, TNF signaling pathway, Toxoplasmosis, Apoptosis, Small cell lung cancer

cIAP2 peptide - ab38273 from Abcam

Category Peptide
Prices $181.00
Sizes 50 µg

Human cIAP2 full length protein - ab167951 from Abcam

Category Protein
Source Baculovirus infected sf9 cells
Species Human
SDS Page analysis of ab167951

Human cIAP2 full length protein - ab112252 from Abcam

Category Protein
Source Wheat germ
Species Human
Coomassie blue stained 12.5% SDS page analysis of ab112252

Human cIAP2 peptide - ab25892 from Abcam

Category Peptide

Human cIAP2 peptide - ab23163 from Abcam

Category Peptide
Species Human

BIRC3 / cIAP2 Antibody Blocking Peptide - LS-E2893 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

BIRC3 / cIAP2 Antibody Blocking Peptide - LS-E27485 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

BIRC3 / cIAP2 Antibody Blocking Peptide - LS-E27486 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

cIAP-2/HIAP-1 Blocking Peptide - NBP1-27972PEP from Novus Biologicals

Category Peptide
Prices $69.00
Sizes 50 µg
Species Human

cIAP-2/HIAP-1 Recombinant Protein - H00000330-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg

BIRC3-Antibody-N-term-Blocking-peptide - BP14020a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Recombinant Human cIAP-2 (HIAP-1), CF - 817-P2-050 from R&D Systems

Category Protein
Source E. coli-derived

BIRC3 Immunizing peptide - orb59961 from Biorbyt

Category Peptide
Prices $247.00
Sizes 100 μg
Species Human, Mouse, Rat

cIAP2 Blocking Peptide - 33R-10658 from Fitzgerald

Category Peptide
Prices $145.00
Sizes 50 µg

cIAP2 Peptide - AC21-2309-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

cIAP2 Peptide - AC21-2310-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

IAP1 / BIRC3 - H00000330-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

IAP1 / BIRC3 - H00000330-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

IAP1 / BIRC3 control peptide - AP00060CP-N from Acris Antibodies

Category Peptide
Prices $205.00
Sizes 50 µg

BIRC3 Peptide - 42-662P from ProSci

Category Peptide
Species Rat

BIRC3 Peptide - 42-663P from ProSci

Category Peptide
Species Human

BIRC3 fusion protein - ag0013 from Proteintech Group

Category Protein
Source E. coli-derived,
Species Human

BIRC3 fusion protein - Ag20143 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human BIRC3 - BIRC3-27246TH from Creative Biomart

Category Protein
Source Wheat germ

Recombinant Human BIRC3, GST-tagged - BIRC3-190H from Creative Biomart

Category Protein
Source Sf9 insect cells using baculovirus
Species Human
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