BIRC3

Gene Symbol BIRC3
Entrez Gene 330
Alt Symbol AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2
Species Human
Gene Type protein-coding
Description baculoviral IAP repeat containing 3
Other Description IAP homolog C|IAP-1|RING finger protein 49|TNFR2-TRAF signaling complex protein|TNFR2-TRAF-signaling complex protein 1|apoptosis inhibitor 2|baculoviral IAP repeat-containing 3|baculoviral IAP repeat-containing protein 3|inhibitor of apoptosis protein 1|mammalian IAP homolog C
Swissprots Q9HC27 Q9UP46 Q13489 Q16628
Accessions AAG09369 AAU88144 CBX47599 CBX47600 EAW67017 Q13489 AA805622 AA873008 AF070674 AAC83232 AI880555 BC027485 BC037420 AAH37420 BE907592 BG569841 BQ718651 BU428906 BX415415 BX475964 L43346 L49432 AAC41943 U37546 AAC50507 U45878 AAC50371 XM_011542797 XP_011541099 NM_001165 NP_001156 NM_182962 NP_892007
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex tha
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15665297}. Nucleus {ECO:0000269|PubMed:15665297}.
Tissue Specificity Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
Top Pathways NOD-like receptor signaling pathway, TNF signaling pathway, Toxoplasmosis, Apoptosis, Small cell lung cancer

Human BIRC3 gene - orb91564 from Biorbyt

Prices $264.00
Sizes 10 μg
Species Human

Human-BIRC3-cDNA-Clone - DC07146 from Abgent, a WuXi AppTec company

Prices $815.40
Sizes 10 µg
Species Human
Accession BC037420

BIRC3 - MBS1273811 from MyBioSource

Species Human
Accession BC037420

Human BIRC3 ORF Clone (BC037420) - CDCS408783 from Creative biogene

Species Human
Accession Q13489
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