ADCY1

Gene Symbol ADCY1
Entrez Gene 107
Alt Symbol AC1, DFNB44
Species Human
Gene Type protein-coding
Description adenylate cyclase 1 (brain)
Other Description 3',5'-cyclic AMP synthetase|ATP pyrophosphate-lyase 1|Ca(2+)/calmodulin-activated adenylyl cyclase|adenyl cyclase|adenylate cyclase type 1|adenylate cyclase type I|adenylyl cyclase 1
Swissprots Q08828 Q75MI1 A4D2L8
Accessions AAS07467 CAD99233 EAL23741 EAW61042 EAW61043 EAW61044 EAW61045 EAW61046 EAW61047 Q08828 AB209496 BAD92733 AF086306 AF497515 AAM94372 AK024415 AK055343 AK095518 AK095665 AL707720 AW956248 BC036858 BC041473 BC169213 BC169214 BU181704 L05500 AAA02907 XM_005249584 XP_005249641 XM_005249585 XP_005249642 NM_001281768 NP_001268697 NM_021116 NP_066939
Function This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O88444}. Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. {ECO:0000250|UniProtKB:O88444}.
Tissue Specificity Brain, retina and adrenal medulla.
Top Pathways Oxytocin signaling pathway, Adrenergic signaling in cardiomyocytes, Inflammatory mediator regulation of TRP channels, Calcium signaling pathway, Gap junction